超高频超声评价己酮可可碱治疗大鼠非酒精性脂肪性肝炎  

EVALUATION OF PENTOXIFYLLINE THERAPY FOR NONALCOHOLIC STEATOHEPATITIS BY HIGH FREQUENCY ULTRASOUND

作　　者：吴静[1] 郑浩[1] 张华[2] 余豪[3] 许晴[2] 史小琳[2] 

机构地区：[1]首都医科大学宣武医院超声诊断科,北京100053 [2]首都医科大学组织胚胎学系,北京100069 [3]首都医科大学肝再生与调节实验室,北京100069

出　　处：《解剖学报》2008年第3期340-344,共5页Acta Anatomica Sinica

基　　金：北京市教委科技发展面上项目(KM200710025003)

摘　　要：目的探讨己酮可可碱治疗大鼠非酒精性脂肪性肝炎的作用。方法68只大鼠随机分为对照组(18只)、模型组(30只)及治疗组(20只),分别于第8周、12周连续4周给予已酮可可碱(PTX)治疗,并在相对应时期进行超声及病理检查,对测量的相关指标进行比较。结果8周模型组肝细胞出现脂肪样变为单纯性脂肪肝,在此基础上12周出现炎性细胞浸润及坏死为中-重度脂肪肝;16周进一步加重,从脂肪性肝炎进展到脂肪性肝纤维化。各组间比较具有显著性差异(P<0.05)。治疗组超声及病理学检查指标均较对照组有明显减轻但无统计学差异。结论己酮可可碱对大鼠非酒精性脂肪性肝炎具有治疗作用。Objective Evaluation of Pentoxifylline（PTX） therapy for nonalcoholic steatohepatitis （NASH） in rats by high frequency ultrasound. Methods Sixtyeight SD rats were randomly divided into normal control （18） and experimental groups （30） were feed by high-fat diet. and therapy groups （20） in 8 and 12 weeks were given the FIX for 4 weeks. Results Fat degeneration commenced after 8 weeks of high-fat diet. The liver enlarged, the edge of the liver became dull, the echo enhanced, and the vessels became indistinct. Those were more marked after 12 weeks. In pathological images, the simple fatty livers were observed in the model group at 8 week. From 12 weeks to 16 weeks, the liver gradually progressed from nonalcoholic steatohepatitis （NASH） to liver fibrosis. The changes exhibited little in therapy groups. There were significant differences of ultrasound and pathological features between control /experimental and therapy group （ P 〈 0.05 ）. Conclusions There were valuation of PTX therapy for NASH in rats.

关 键 词：非酒精性脂肪性肝炎 己酮可可碱 超高频超声 大鼠 

分 类 号：R329.3[医药卫生—人体解剖和组织胚胎学]