紫外线减毒弓形虫免疫对小鼠旋毛虫感染肌肉组织病理的影响  

Immunization with UV-Attenuated Toxopalsma gondii Influences Pathology of Muscular Trichinella spiralis in Mouse Model

作　　者：郑焕钦[1] 朱佩娴[2] 许少明[1] 张瑞琳[3] 黄世光[2] 吕芳丽[1] 

机构地区：[1]中山大学中山医学院寄生虫学教研室教育部热带病防治研究重点实验室,广州510080 [2]暨南大学医学院,广州510632 [3]中山大学基础医学实验教学中心,广州510080

出　　处：《热带医学杂志》2008年第5期447-449,共3页Journal of Tropical Medicine

基　　金：广东省自然科学基金(No.06021302);教育部留学回国人员科研启动基金(教外司留[2006]331号);中山大学中山医学院留学回国人员启动基金

摘　　要：目的探讨紫外线减毒弓形虫免疫对小鼠旋毛虫感染肌肉期组织病理的影响。方法ICR小鼠分为两组,实验组为紫外线减毒弓形虫免疫3周后再感染旋毛虫,对照组为旋毛虫单独感染。结果与旋毛虫单感染相比,小鼠预先经紫外线减毒弓形虫免疫再感染旋毛虫后23d,其肌肉期幼虫周围的炎症细胞浸润明显减轻,肌肉组织的病理损伤也明显减轻。结论紫外线减毒弓形虫免疫对小鼠旋毛虫感染肌肉期的组织病理有一定的免疫调节作用。Objective To investigate the possible influence of the immunological environment created by immunization with UV-attenuated Toxoplasma gondii in the development of Trichinella spiralis of muscle phase in mouse models. Methods Mice of experimental group were immunized with UV-attenuated T. gondii, then infected with T. spiralis ; mice infected with T. spiralis alone as control. Results There were significant higher adult worm burdens in the small intestine and lower larva burdens in muscle tissues. Conclusion Mice immunized with UV-attenuated T. gondii could limit the inflammation of muscular T. spiralis infection.

关 键 词：旋毛虫 弓形虫 肌肉期 

分 类 号：R383.15[医药卫生—医学寄生虫学] R382.5[医药卫生—基础医学]