病毒性肝炎患者血清中肝纤维化标志物的检测及分析  

Analysis of Serum Fibrosis Markers in Hepatitis Patients

作　　者：李石好[1] 叶晓光[1] 徐建英[1] 唐正运[1] 

机构地区：[1]广州医学院第二附属医院感染科,广州510260

出　　处：《热带医学杂志》2008年第5期469-470,共2页Journal of Tropical Medicine

摘　　要：目的探讨病毒性肝炎患者血清中肝纤维化标志物的水平及意义。方法酶标法检测基质金属蛋白酶-1(MMP-1)、基质金属蛋白酶抑制剂-1(TIMP-1)和转化因子-β1(TGF-β1),放免法检测转化因子"(TGF-")、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(C-Ⅳ)和层粘蛋白(LN)。结果病毒性肝炎患者血清中TIMP-1、HA、PCⅢ、C-Ⅳ和LN水平与对照组比较明显升高(P<0.01);MMP-1、TGF-β1水平与对照组比较差异无统计学意义(P>0.05)。结论病毒性肝炎患者血清中肝纤维化标志物中TIMP-1、HA、PCⅢ、C-Ⅳ和LN具有较好的临床价值,MMP-1、TGF-β1价值欠佳。Objective To evaluate the clinical significance of serum fibrosis markers in patients with viral hepatitis. Methods Levels of serum MMP-1, TIMP-1 and TGF-β1 were measured by ELISA method. RIA was used to measure TGF-α, HA, PC Ⅲ, C-Ⅳ and LN. Results The levels of TIMP-1, HA, PC Ⅲ, C-Ⅳ and LN in the hepatitis patients were higher than the control group （P〈0.01）. The levels of MMP-1 and TGF-β1 in the hepatitis patients were not significantly different from the control group （P〉 0.05）. Conclusion TIMP-1, HA, PC Ⅲ, C-Ⅳ and LN may be used as markers for detecting liver fibrosis in hepatitis patients.

关 键 词：病毒性肝炎 肝纤维化 标志物 

分 类 号：R512.6[医药卫生—内科学]