黄芪精口服液防治小儿反复呼吸道感染的临床观察  

Clinical Effect of Milkvetch Extract Oral Liquid in Preventing and Treating Children's Recurrent Respiratory Tract Infection

作　　者：杨善浦 董虹[1] 吴月超 苏华[1] 吴叶健 黄爱萍[1] 

机构地区：[1]浙江省玉环县人民医院,浙江317600

出　　处：《中国中西医结合杂志》2008年第6期544-547,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察黄芪精口服液防治小儿反复呼吸道感染(RRI)的临床疗效和对免疫功能的影响。方法72例患儿分为3组,黄芪组23例,转移因子组23例及乌体林斯组26例,观察3组的临床疗效及治疗前后T细胞亚群(CD_3^+、CD_4^+、CD_+^+)和免疫球蛋白(IgA、IgM、IgG)的变化。结果黄芪组、转移因子组和乌体林斯组的显效率分别为69.6%、65.2%、73.0%,总有效率分别为87.0%、82.6%、92.3%,3组比较,差异均无统计学意义(P>0.05)。治疗后3组CD_3^+、CD_4^+、CD_4^+/CD_8^+比值均较治疗前显著增高(P<0.05);黄芪组和转移因子组治疗后CD_8^+均显著下降(P<0.05,P<0.01);治疗后T细胞亚群变化3组之间差异无统计学意义(P>0.05)。黄芪组、转移因子组和乌体林斯组治疗后血清IgG水平较治疗前均有显著增高(P<0.01);治疗后转移因子组和黄芪组IgA水平显著增高(P<0.05,P<0.01),并且转移因子组与其他两组差异有统计学意义(P<0.01);乌体林斯组和黄芪组治疗后IgM明显增高(P<0.01,P<0.05)。结论黄芪精口服液、转移因子口服液和乌体林斯注射剂的临床疗效和免疫学指标的转归相近,均可提高机体免疫功能,增强抗病能力,降低RRI的发病率。以黄芪精口服液费用低廉,方法简便,免注射痛苦,患儿依从性好而值得临床推广使用。Objective To explore and compare the clinical effects of three immuno-potentiators and their influence on immune function in preventing and treating recurrent respiratory tract infection （RRI）. Methods Seventy-two children with RRT were assigned to three groups, the 23 patients in the M group treated with milkvetch extract oral liquid, the 23 in the P group treated by P-transfer factor and the 26 in the U group treated by Utilins injection. Clinical effect was compared among three groups after treatment, and changes of T cell subgroups as well as immune antibodies were detected before and after treatment. Results The markedly effective rate in the M, P, and U group was 69.6% , 65.2% , and 73.0% respectively, and the total effective rate 87.0% , 82. 6% , and 92. 3%, showing an insignificant difference among them （all P 〉 0. 05）. After treatment, the levels of CD3^＋ ,CD4^＋ and CD4^＋/CDs rose obviously in the three groups （ all P 〈 0. 05 ） ; levels of CDs in the M group and the P group lowered significantly （P 〈0. 05, P 〈0.01 ） , but with no significant difference among three groups in the changes of T cell subgroups （all P 〉 0.05）. Serum levels of IgG in all the three groups, IgA in the P group and the M group, and IgM in the M group and the U group rose significantly （P 〈0. 05 or P 〈0.01 ） , with statistical difference presented in comparing of IgA level in the P group with that in the other two groups （P 〈 0.01 ）. Conclusion Theclinical effects and the outcomes of immunological indexes＇ changing are similar in RRI patients treated by the three immuno-potentiators. They all can enhance the immunological function of the organism, strengthen the disease-resistant ability of patients, and reduce the incidence of RRI. Among them, the milkvetch extract oral liquid is worthy of spreading due to its lower cost, simple administration, exemption from painful injection, and good compliance.

关 键 词：黄芪精口服液 反复呼吸道感染 T细胞亚群 免疫球蛋白 

分 类 号：R272[医药卫生—中医儿科学]