人巨细胞病毒感染中的细胞免疫机制  

Mechanism of cellular immunity in the human cytomegalovirus infection

作　　者：赵宏[1] 马伟杭[1] 

机构地区：[1]浙江大学医学院附属第一医院传染病研究所,传染病诊治国家重点实验室,杭州310003

出　　处：《国际流行病学传染病学杂志》2008年第3期182-184,I0004,共4页International Journal of Epidemiology and Infectious Disease

基　　金：国家973项目（2007CB513005）;国家自然科学基金（30471631）;浙江省卫生厅基金（2002ZX028,20058B42）

摘　　要：人巨细胞病毒（HCMV）在人群中普遍易感，免疫力正常者多为隐性感染，可终身携带病毒。感染后，病毒激活机体免疫系统，产生病毒清除作用。在机体清除HCMV的免疫应答中，与机体其他免疫相比，固有免疫中的免疫细胞和获得性免疫中的细胞免疫起着更为重要的作用，同时巨细胞病毒也通过一系列的逃逸反应来对抗上述免疫的清除作用。Human cytomegalovirus is one of the most common viral opportunistic pathogen among patients. Most of infections are generally asymptomatic or self-healing. The immune system of host is activated after being infected in order to eliminate the pathogen. Immunocyte and cellular immunity play much more important roles during the reaction compared with other immunities. Meanwhile, human cytomegalovirus may take some escape reactions against the cell-mediated immunity.

关 键 词：巨细胞病毒 细胞 免疫 逃逸反应 

分 类 号：R3[医药卫生—基础医学]