法莫替丁生物黏附缓释片释放机制研究  

Study on Release Mechanism of Famotidine Bioadhesive Sustained-Release Tablets

作　　者：陈日来 李玉珍[2] 李东 刘新宇[2] 徐玉红[2] 李衡梅 李红侠 

机构地区：[1]广东省深圳市梅林医院,广东深圳518049 [2]广东省深圳市第四人民医院,广东深圳518033 [3]暨南大学第二临床医学院.广东省深圳市人民医院,广东深圳518020

出　　处：《中国药业》2008年第13期11-12,共2页China Pharmaceuticals

基　　金：深圳市科技计划(医疗卫生类)项目;项目编号:200703222

摘　　要：目的探讨法莫替丁生物黏附缓释片的释药机制及影响因素。方法以羟丙基甲基纤维素(HPMC)为骨架材料,卡波姆为生物黏附材料,乳糖为辅料制备生物黏附缓释片,运用Ritger-Peppas方程释放指数n值,评价HPMC、卡波姆和乳糖对释药速率的影响。结果生物黏附片的释药速率随HPMC、卡波姆含量增高而减慢,乳糖可以加快释药速率,经处方筛选优化后制备的法莫替丁生物黏附缓释片的释放,是Fick扩散和凝胶骨架溶蚀两种机制的协同作用结果。结论HPMC、卡波姆和乳糖均可影响法莫替丁生物黏附片中主药的释放,生物黏附缓释片的释药过程可用Ritger-Peppas方程进行描述。Objective To study the release mechanism of famotidine bioadhesive sustained-release tablets and the factors influencing the release rate. Methods The bioadhesive sustained- release tablets were prepared by using hydroxypropyl methylcellulose （HPMC） as the matrix material,carbomer as the bioadhesive reagent and lactose as the dressing. The effects of the amounts of HPMC,carbomer and lactose on the drug release from tablets were appraised with the release index n value of the Ritger- Peppas equation. The release mechanism of the tablets was fitted by Ritger-Peppas equation. Results The rate of drug release was slowed down along with the increase of the amount of HPMC or carbomer. The addition of lactose speeded up the rate of drug release from tablets. The drug release of tablets from optimized formulation was the coupled action of Fick diffusion and erosion mechanism. Conclusion The release of famotidine bioadhesive sustained- release tablets is influenced by the amount of HPMC,carbomer and lactose. The release process can be depicted by Ritger- Peppas equation.

关 键 词：法莫替丁 生物黏附缓释片 释药机制 

分 类 号：R945[医药卫生—微生物与生化药学] R975.6[医药卫生—药剂学]