MSCs定向诱导移植修复关节软骨的实验研究  

Study of Transplant Chondrogenic Diferentiation of Mesenchymal Stem Cells in Vitro for Repairing Articular Cartilage

作　　者：田力[1] 梁晓鹏[1] 范妮娜[1] 田晓晔[1] 汪卓[1] 李娜[1] 

机构地区：[1]沈阳医学院临床实验中心,沈阳110034

出　　处：《世界科技研究与发展》2008年第3期352-354,共3页World Sci-Tech R&D

基　　金：辽宁省科技厅资助项目(2005225017)

摘　　要：目的用组织工程方法修复软骨损伤。方法兔骨髓间充质干细胞体外扩增诱导分化后,移植于兔关节损伤区,术后进行大体及x线观察。结果实验组移植8周后,软骨损伤区由透明软骨样组织填充,软骨修复良好。结论自体间充质干细胞移植可修复关节软骨损伤。Objective To repair the articular cartilage defects by means of tissue engineering. Methods Rabbit bone marrow mesenchymal stem cell were cultured and multiplied in vitro. After MSC induced were transplanted in rabbit articular injury, and a general observation x line. Results 8 weeks after transplantation ,cartilage damage filled by hyaline cartilage-like tissue ,well cartilage repaired. Conclusion autol- ogous mesenchymal stem cell transplantation repair articular cartilage injury.

关 键 词：骨髓间充质千细胞 软骨 关节 

分 类 号：R684[医药卫生—骨科学]