低氧适应对糖代谢的影响及其机制  

Mechanism and the effect of hypoxic acclimatization on glycometabolism

作　　者：周燚[1] 李良鸣[1] 方彩华[1] 

机构地区：[1]广州体育学院

出　　处：《中国组织工程研究与临床康复》2008年第24期4745-4748,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：广州体育学院科研管理资助项目(07YGYB05)~~

摘　　要：学术背景:低氧应激状态下糖作为首当其充的能源物质优先被动用,长期低氧应激机体糖代谢过程发生深刻影响,包括糖的摄取、利用、氧化等。因此研究低氧适应对糖代谢的影响及其机制尤为必要。目的:探讨低氧适应对糖代谢的影响及其可能机制,为低氧应用研究提供理论参考。检索策略:应用计算机检索PubMed数据库和中国期刊全文数据库1990-01/2007-07的有关文献,检索词为"低氧(缺氧),代谢酶,胰岛素,GLUT,HIF-1,AMPK",限定文章语言分别为英语和中文。共检索到338篇相关文献,其中中文文献215篇,英文文献123篇,对文献进行筛选,纳入标准:①选取针对性强,相关度高的文献。②对同一领域的文献选择近期发表或权威杂志的文献;排除重复研究和Meta分析类文章。最后40篇被选用。文献评价:选用40篇文献,其中8篇为综述、其余均为临床与实验研究。资料综合:伴随着低氧适应,机体糖磷酸化酶与糖原合成酶含量升高、活性增强,葡萄糖转运能力增强,可能是低氧诱导因子1上调了糖代谢有关的低氧基因表达;AMPK的激活通过一条未知的途径调节糖代谢过程。结论:糖代谢能力增强是低氧适应的重要标志之一;低氧适应糖代谢能力增强,在高原训练、预防和改善胰岛素抵抗方面有着广泛的应用前景。BACKGROUND： Under hypoxic environment carbohydrate is consumed preferentially to supply energy. Long-term hypoxic stress has profound influence on the metabolic process such as the intake, utilization and oxidization of glucose. Therefore, it is necessary to explore the effects and mechanism of hypoxic stress on glucose metabolism. OBJECTIVE： To explore the possible mechanism of the effect of hypoxic acclimatization on glycometabolism, so as to provide theoretical fundament for related studies. RETRIEVE STRATEGY： The relevant English and Chinese articles dated between January 1990 and July 2007 were retrieved from PubMed and China Journal Full-text Database （CJFD） by using the keywords of ＂hypoxia, metabolic enzyme, insulin, GLUT, HIF-1 and AMPK＂ in English and Chinese. 338 literatures were retrieved, including 215 Chinese, and 123 English. Articles with close association and published in recently or in the authoritative journals were included. Repetitive articles and Meta analysis articles were excluded. Forty literatures were selected. LITERATURE EVALUATION： Of 40 included articles, 8 were review articles, and the others were clinical and experimental researches. DATA SYNTHESIS： With hypoxic acclimatization, the amount of saccharophosphorylase and glycogen synthetase is increased, the activity enhanced and the ability to transfer glucose promoted. The possible mechanism of the effect of hypoxic acclimatization on glycometabolism is that hypoxia inducible factor-1 up-regulates the expression of hypoxia responsive genes about glycometabolism and the activation of the AMP-activated protein kinase regulates the process of glycometabolism through an unknown pathway. CONCLUSION： The enhancement of glycometabolism is one of the important signs of hypoxic acclimatization. The increase in the capability of glycometabolism under hypoxia has extensive application prospects in the field of the altitude training and the prevention and improvement of insulin-resistant conditions.

关 键 词：低氧适应 糖代谢 HIF-1 AMPK 

分 类 号：R319.14[医药卫生—基础医学]