慢性肾脏病患者心脑血管并发症流行病学意义  

The epidemiologic significance of cerebrocardiovascular syndromes in patients with chronic kidney disease

作　　者：刘思圆[1] 汪年松[1] 

机构地区：[1]上海交通大学附属上海市第六人民医院肾脏科,200030

出　　处：《老年医学与保健》2008年第3期154-156,共3页Geriatrics & Health Care

基　　金：上海市自然科学基金(编号:052R14086);上海市医苑新星基金(编号:02XX846)资助

摘　　要：目的探讨慢性肾脏疾病(CKD)患者的心脑血管并发症的发生率,分析心脑血管并发症的危险因素。方法采用专用调查表进行问卷调查的方式,研究CKD患者心脑血管并发症发生率,以及心脑血管并发症与CKD之间相互影响的情况。结果CKDⅠ～Ⅴ期患者共129例,其中男性57例,女性72例。CKD主要并发疾病依次为高血压(69.0%)、贫血(44.2%)、高血脂(43.4%)、心脏疾病(41.9%)、糖尿病(30.2%)等。肾小球滤过率(GFR)水平降低和高血压为CKD并发CVD的危险因素;C反应蛋白(CRP)水平、高血脂、年龄增加皆为脑血管并发症的危险因素。结论GFR水平降低、高血压、CRP水平升高、高血脂、年龄增加为CKD心脑血管并发症的主要危险因素。早发现CKD并发症和严重程度,重视各种危险因素对CVD和CKD的影响有重要意义。Objective To investigate the occurrence rate of cerebrocardiovascular syndromes in patients with chronic kidney disease （CKD） and analyze risk factors ofcerebrocardiovascular syndromes. Methods Using a specific questionnaire form, the occurrence rate of cerebrocardiovascular syndromes, and the interaction between cerebrocardiovascular syndromes and CKD were analyzed. Results Of 129 CKD patients from stage Ⅰ-Ⅴ, 57 were male and 72 were female. The main syndromes of CKD were hypertension （ 69.0 % ）, anemia （ 44.2 % ）, hyperlipidemia （43.4 % ）, heart disease （ 41.9 % ） and diabetes mellitus （ 30.2 % ）. Hypertension and the degression of GFR level were the risk factors of CKD patients with CVD syndrome, while the growth of CRP level, hyperlipidemia and the growth of age were all risk factors of cerebral syndrome. Conclusions The degression of GFR level, hypertension, the growth of CRP level, hyperlipemia and the growth of age are main risk factors of cerebrocardiovascular syndromes in CKD patients. It is vital to find the syndromes of CKD and their degree of impaction as early as possible and attach importance to the influence of the risk factors to CVD and CKD.

关 键 词：慢性肾脏疾病 心脑血管并发症 危险因素 

分 类 号：R692[医药卫生—泌尿科学] R181.3[医药卫生—外科学]