淋球菌流行株抗生素敏感性监测  

Surveillance of gonococcal antibiotic susceptibility in Guangzhou

作　　者：吴兴中[1] 郑和平[1] 曾维英[1] 黄进梅[1] 潘慧清[1] 李美玲[1] 

机构地区：[1]广东省皮肤性病防治中心,广东广州510500

出　　处：《岭南皮肤性病科杂志》2008年第3期121-123,共3页Southern China Journal of Dermato-Venereology

摘　　要：目的:监测广州地区2007年度分离的淋球菌对青霉素、四环素、大观霉素、头孢曲松和环丙沙星的敏感性,分析耐药菌株的流行特点。方法:采用琼脂稀释法测定菌株对5种抗生素的最小抑菌浓度(MIC),判断敏感性按WHO西太区淋球菌耐药性监测统一标准。用纸片酸度法检测产β-内酰胺酶淋球菌(PPNG)菌株。结果:123株淋球菌中检出115株对青霉素耐药(93.5%),产β-内酰胺酶淋球菌(PPNG)39株(占31.7%);四环素耐药率为87%,其中质粒介导高度耐四环素淋球菌(TRNG)为72株,占58.5%;环丙沙星耐药率为91.1%;未发现对大观霉素和头孢曲松耐药菌株。青霉素、四环素和环丙沙星的MIC50及MIC90均已超过耐药标准,尤以青霉素为甚,其MIC50及MIC90均超过耐药标准的8倍和大于32倍。结论:淋球菌对大观霉素和头孢曲松的敏感性较高,可作为治疗的首选药物,对青霉素、四环素和环丙沙星耐药率较高,提示对淋病的治疗作用差。Objective： To survey the antibiotic susceptibility trend of Neisseria gonorrhoeae strains isolated in Guangzhou in 2007. Methods：The agar dilution method was used to determine the minimum inhibitory concentrations （MICs） to five antibiotics： penicillin G, tetracycline, ciprofloxacin, ceftriaxone and spectinomycin, the results were interpreted according to criteria used in the project of surveillance of gonococcal antibiotic susceptibility in the WHO Western Pacific Region. Penicillinase- producing N. gonorrhoeae （PPNG） was detected by the paper acidimetric method. Results： 123 gonococcal strains isolated in Guangzhou in 2007 were studied. Penicillinresistant rate was 93.5% （112/123） and PPNG 31.7% （39/123）. 87% of the strains were tetracycline -resistant, of which 58.5% were TRNG strains. The ciprofloxacin-resistance rate was 91.1%. None of the strains was found to be resistant to ceftriaxone and spectinomycin. MICs0 and MIC90 of Penicillin were 8 and over 32 times higher than the criteria. Conclusion： Penicillin, tetracycline and ciprofloxacin resistant strains spread seriously in Guangzhou. Ceftriaxone and spectiomycin should be used as the first-line agents in treating gonorrhoea.

关 键 词：淋球菌 敏感性 抗生素 微生物敏感性试验 

分 类 号：R446.5[医药卫生—诊断学]