灵芝多糖对阿尔茨海默病大鼠学习记忆影响及与海马细胞凋亡的关系  

Relationship between effects of ganoderma lucidum polysaccharides on learning and memory in Alzheimer's disease rats and apoptosis of hippocampus cells

作　　者：郭燕君[1] 李平[1] 袁华[2] 

机构地区：[1]嘉兴学院医学院解剖学教研室,嘉兴314001 [2]武汉大学医学院人体解剖学与组织胚胎学系,武汉430071

出　　处：《解剖学杂志》2008年第3期376-378,393,共4页Chinese Journal of Anatomy

摘　　要：1／1的：观察灵芝多糖（GLP）对阿尔茨海默病（AD）模型大鼠学习记忆影响并探讨其与海马细胞凋亡的关系。方法：用立体定位技术对海马CA1区微量注射Aβ25-35造成AD模型；Morris水迷宫检测大鼠记忆水平；电子显微镜、流式细胞仪检测海马凋亡。结果：GLP可明显提高Aβ25-35所致痴呆大鼠学习记忆水平，显著降低海马细胞凋亡率。结论：GLP对AD大鼠的保护作用与降低海马细胞凋亡率有关。Objective： To observe the relationship between effects of ganoderma lucidum polysaccharides （GLP） on learning and memory in Alzheimer＇s disease （AD） rats and apoptosis of the hippocampus cells. Methods： The AD pathological model was made by hippocampal CA1 lesions due to stereotaxic mini-injection of Aβ 25-35, and the learning and memory of rats were observed by Morris water maze; the apoptosis of hippocampal cells were detected by using flow cytometry and electronic microscope. Results ： Compared with the control group, GLP was shown to improve learning and memory in rats with bilateral hippocampal lesions, and to decrease apoptosis rate in hippocampal cells significantly. Conclusion ： These results suggest that the protective effects of GLP on AD rats may be related to its ability to decrease the apoptosis rate of hippocampal cells.

关 键 词：灵芝多糖 阿尔茨海默病 学习 记忆 海马 细胞凋亡 

分 类 号：R285.5[医药卫生—中药学]