丁咯地尔对大鼠坐骨神经损害的保护作用  

Protective effects of buflomedil on sciatic nerve crush lesion in rats

作　　者：苏建华[1] 章莉萍[1] 陈玉芳[2] 唐金荣[3] 肖杭[4] 包德诚[1] 

机构地区：[1]金坛市人民医院神经内科,江苏金坛213200 [2]常州市第四人民医院病理科,江苏常州213001 [3]南京医科大学第一附属医院神经内科,江苏南京210029 [4]南京医科大学应用神经毒理研究所,江苏南京210029

出　　处：《中国新药与临床杂志》2008年第6期425-428,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：江苏省常州市卫生局资助项目(2004182)

摘　　要：目的观察丁咯地尔对坐骨神经损害后恢复的影响。方法SD大鼠100只随机分为正常组、模型组、甲钴胺组(阳性对照组,104μg·kg^(-1))、丁咯地尔组(40 mg·kg^(-1))。以大鼠坐骨神经挤压伤建立动物模型,以坐骨神经传导速度、坐骨神经干病理切片(光镜、电镜)为观察指标,考察丁咯地尔对坐骨神经损害后恢复的影响。结果wk 4时甲钴胺组和丁咯地尔组均能显著增加坐骨神经传导速度,甲钴胺组与模型组比较有显著差异(P<0.05),丁咯地尔组与模型组比较有非常显著差异(P<0.01);4 wk时丁咯地尔组和甲钴胺组髓鞘形态结构接近正常,而模型组神经髓鞘溃变程度很高。结论丁咯地尔对坐骨神经损害有确切的修复作用。AIM Study on protective effects of buflomedil to sciatic nerve crush lesion in rats. METHODS One hundred SD rats were randomly divided into normal group, model group, mecobalamin group （104 μg·kg^-1） , and buflomedil group （40 mg·kg^-1）. Sciatic nerve crush lesion model were established in rats. The conduction velocity of sciatic nerve and the morphological changes were observed by light and electron microscope. RESULTS At the end of 4 weeks, the conduction velocity of buflomedil group increased obviously as well as methycobal group, with significant difference （P 〈 0.05, P 〈 0.01）. Almost normal myelin was observed in the buflomedilgroup and mecobalamin group, and the severe degeneration was observed in the model group. CONCLUSION Buflomedil shows recovery effects on the sciatic nerve crush lesion.

关 键 词：丁咯地尔 创伤 神经系统 大鼠 

分 类 号：R961[医药卫生—药理学]