厄贝沙坦对高血压左心室肥厚及血浆内皮素的影响  

The effect of hypertrophy and changes of plasma endothelin by irbesartan in elderly patients with essential hypertension

作　　者：万大国 张卫国 杨展 包小妹 Wan Daguo, Zhang Weiguo, Yang Zhan,et al. （ Cardiac department, The second affiliated hospital ,Zhengzhou University）

机构地区：郑州大学第二附属医院,河南郑州450014

出　　处：《中国保健》2008年第13期360-361,共2页Chinese Health Care

摘　　要：目的：研究厄贝沙坦对老年高血压性左室肥厚的逆转及对血浆内皮素（ET）的影响。方法：以20例健康老年人为对照组，观察单纯高血压32例（EH组）、高血压伴左室肥厚26例（LVH组）在每日服厄贝沙坦150mg前及16w后血压、ET的变化。用超声心动图观察LVH组在用药前后的左室舒张末期内径（LVDd）、室间隔厚度（IVST）、左室后壁厚度（LVPWT）、左室重量（LVM）、左室重量指数（LV—MI）的变化。结果：经厄贝沙坦治疗后，EH组、LVH组的平均动脉压（MAP）及ET水平有显著性下降；LVH组的ET水平与LVM、LVMI呈正相关，LVH组在治疗后IVST、LVPWT、LVDd、LVM、LVMI亦有显著性下降。结论：厄贝沙坦对高血压病人具有良好的降压效果，同时具有逆转LVH及降低ET的作用。Objective：To study the effect of left ventricnlar hypertrophy（LVH） and changes of plasma endothelin（ET） in patients with essential hypertension （EH） by irbesartan. Methods： The changes of plasma ET and blood pressure in 26 hypertensive patients with LVH （ LVH group） and 32 essential hypertensive patients without LVH（EH group）before and after irbesartan 150 mg per day treatment for 16w were observed compared with 20 normotensive. The left ventricnlar posterior wall thickness （LVPWT）, the interyentricnlar septalthickness （IVST）, left ventricular end diastolic dimension（LVDd） ,left ventricnlar mass （LVM）and left ventricular mass index （LVMI）before and after irbesartan treatment in LVH group, were measured by ediocardiography. Results ：The mean arterial pressure（MAP） and plasma ET in EH and LVH group were significantly decreased after irbesartan treatment, a positive correlation between the plasma ET in LVH group and LVM, LVMI was found. LVDd, IVST, LVPWT, LVM and LVMI in LVH group were also significantly reduced after irbesartan treatment. Conclusion ： The therapy with irbesartan in elderly EH patients can not only effectively decrease blood pressure and plasma ET but also beneficialy reverse LVH.

关 键 词：高血压 左心室肥大 血浆内皮素 厄贝沙坦 

分 类 号：R544.1[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]