差示扫描量热法(DSC)定量测试阿德福韦酯晶型的研究  

Study on Quantitative Analysis of Crystal forms of Adefovir Dipivoxil by Differential Scanning Calorimetry

作　　者：袁钻如[1] 张爱明[2] 方江邻[1] 

机构地区：[1]南京大学现代分析中心,江苏南京210093 [2]江苏正大天晴药业股份有限公司,江苏连云港222006

出　　处：《分析测试技术与仪器》2008年第2期105-108,共4页Analysis and Testing Technology and Instruments

摘　　要：红外光谱(FTIR)和X-射线衍射(XRD)测试表明阿德福韦酯药物具有A、E 2种晶型.利用差示扫描量热法(DSC)对阿德福韦酯药物的不同晶型进行了定量测试方法的研究,该方法的依据是药物的不同晶型具有不同的熔点和熔融热焓,根据熔融热焓的量可以定量测试药物中某种晶型的含量,为指导生产工艺研究和产品品质的判断提供快速准确及有效的测试方法.Adefovir dipivoxil contains two crystal forms of A and E by analysis of Fourier transform infrared spectroscopy（FTIR）and X-ray diffractometer（XRD）. It is certified that the Quantitative Analysis of Crystal forms of Adefovir dipivoxil can be used by the method of Differential Scanning Calorimetry （DSC）. The method is based on the principle that different crystal forms show the different melting point and molten enthalpy. The molten enthalpy is corresponding to the amount of the crystal form. It is a useful and rapid method of guiding the production technology and the control of product quality.

关 键 词：阿德福韦酯 晶型 差示扫描量热法 红外光谱 X-射线衍射 定量测试 

分 类 号：O657.32[理学—分析化学]