脯氨酰胺催化的不对称直接Aldol反应  

L-Prolinamide Catalysted Asymmetric Direct Aldol Reaction

作　　者：王雪莲[1] 刘全忠[1] 

机构地区：[1]西华师范大学化学化工学院,四川南充637002

出　　处：《西华师范大学学报（自然科学版）》2008年第2期173-176,190,共5页Journal of China West Normal University(Natural Sciences)

摘　　要：Boc保护的L-脯氨酸与Suzuki偶联得到的联苯衍生的胺化合物反应,经过脱去Boc保护基得到脯氨酰胺催化剂,该催化剂与三氟乙酸组合可有效的催化芳香醛和酮的不对称直接Aldol反应,最高得到了91%的产率和87%的对映体过量值.An enantioselective Aldol reaction was catalyzed by prolinamide derived from the Boc protected L-proline and 2＇ - aminobiphenyl-2-ol. 20 mol % of the catalyst in combination with 5 mol % of trifluoracetic acid which was found to be effective catalyst in the direct aldol reaction of ketones with aldehydes, affording the coreesponding product in the yield of up to 91% and good enantioselectivity up to 87% ee.

关 键 词：SUZUKI偶联 脯氨酰胺 有机催化 不对称 直接ALDOL反应 

分 类 号：O626.1[理学—有机化学]