2004-2006年产超广谱β-内酰胺酶肺炎克雷伯菌的检出率和耐药性分析  

Analysis of detection rate and drug resistance of ESBLs-producing K.pneumoniae strains from 2004 to 2006

作　　者：陈曼丹[1] 辜红妮[1] 姚映斐[1] 林广玲[1] 

机构地区：[1]汕头大学医学院附属第二医院检验科,515041

出　　处：《国际检验医学杂志》2008年第6期515-516,519,共3页International Journal of Laboratory Medicine

摘　　要：目的分析和对比医院2004-2006年产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌的检出率和耐药情况。方法用VITEK-AMS微生物自动分析仪鉴定菌种和药物试验,同时对肺炎克雷伯菌进行ESBLs检测。结果产ESBLs肺炎克雷伯菌株检出率在2004、2005、2006年分别为20.5%、34.1%、41.9%,新生儿科连续3年产ESBLs检出率最高;未发现对亚胺培南耐药的菌株,产ESBLs菌株对第3代头孢菌素类、复方新诺明有极高耐药性,均高于非产ESBLs菌株。结论产ESBLs肺炎克雷伯菌株呈现逐年增加趋势,医生应慎重使用头孢菌素类抗生素,减少产ESBLs菌株的产生,防止其暴发与流行。Objective To analyze and compare the detection rate and drug resistance of extended spectrum β lactamases （ESBLs）-producing K. pneumoniae strains in our hospital from 2004 to 2006. Methods VITEK-AMS microbial autoanalyzer was applied to identifying strain species and drug susceptibility test, while ESBLs test was carried out for the isolated K. pneunoniae strains. Results The detection rates for ESBLs producing K. pneumoniae were 20. 5%, 34. 1 % and 41. 9% in 2004, 2005 and 2006 respectively. Especially for Department of Newborns, the detection rate kept the highest over the three years. Imipenem-resistant strains weren＇t detected. ESBLs-producing strains were steeply resistant to the third generation cephalosporins and bactrim, much higher than non-ESBLs producing strains. Conclusion ESBLs-producing K. pneumoniae shows a tendency of increasing year by year. The cephem antibiotics should be used cautiously so as to reduce the heneration of ESBLs-producing K. pneumoniae strains and to prevent outbreak and prevalence of ESBLs producing K. pneumoniae infection.

关 键 词：克雷伯菌 肺炎 Β-内酰胺酶类 抗药性 细菌 

分 类 号：R446.5[医药卫生—诊断学]