三步法合成高封端率端氨基聚乳酸  

Synthesis of Amino-Terminated Poly(Lactic Acid)

作　　者：于博昊[1] 龚飞荣[1] 赵燕超[1] 饶炬[1] 程树军[1] 

机构地区：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237

出　　处：《功能高分子学报》2008年第2期182-187,共6页Journal of Functional Polymers

基　　金：上海市科委资助项目(044319213)

摘　　要：叔丁氧羰基碳酸酐((Boc)2O)和氨基丙醇反应合成叔丁氧羰基氨基丙醇(Boc-氨基丙醇),以此为引发剂在辛酸亚锡的催化下,引发L-丙交酯开环聚合合成叔丁氧羰基氨基封端聚乳酸(BocNH-PLLA),叔丁氧羰基(Boc)经三氟乙酸处理脱除后得到端氨基聚乳酸(PLLA-NH2)。以PLLA-NH2为大分子引发剂,引发ω-苄氧羰基L-赖氨酸-N-羧酸酐(ω-Z-L-Lysine-NCA)开环聚合,合成聚L-乳酸-聚ω-苄氧羰基L-赖氨酸两嵌段共聚物(P(LLA-LLz))。采用红外光谱(FT-IR)、核磁共振氢谱(1H-NMR)、凝胶渗透色谱(GPC)对聚合物结构进行了表征。结果表明:PL-LA-NH2端基亲核性明显提高,可引发ω-Z-L-Lysine-NCA开环聚合制备嵌段共聚物,PLLA-NH2的合成方法简便,氨基封端率高,其分子量和单体与引发剂的摩尔比具有良好的线性关系。Amino-terminated poly（lactic acid） was synthesized in three steps： （1） protection of the amino group in amino propanol by Boc group; （2） ring opening polymerization of L lactide with Boe amino pro- panol as an initiator and Sn（Oct）2 as a catalyst; （3） dcprotection of the t3oc group. The nucleophilicityof amino-terminatal poly（lactic acid） was estimated as a macroinitiator by initiating the polymerization of N-carboxyanhydride of ω-benzyloxycarbonyl-L-lysine. The polymers were characterized by FT IR, ^1HNMR and GPC. The results show that the synthesis of amino-termed poly（lactic acid） can be easily carried out with high amino ratio and each length of the block can he controlled from the ratio of monomer to initiator.

关 键 词：聚乳酸 端基改性 赖氨酸 

分 类 号：TB324[一般工业技术—材料科学与工程]