反应性氮代谢物在白血病中的多重作用  

The Multiplicitive Roles of Reactive Nitrogen Metabolites on Leukemia

作　　者：郑美珠(综述)[1] 潘敬新[1] 陈志哲(审校)[2] 

机构地区：[1]福建医科大学附属第二医院血液内科,福建泉州362000 [2]福建省血液病研究所,福建医科大学附属协和医院血液科,福州350001

出　　处：《医学综述》2008年第13期1921-1923,共3页Medical Recapitulate

基　　金：福建省科技厅资助省属高校项目(2007F5043)

摘　　要：反应性氮代谢物(RNM)是机体代谢过程中,由细胞内存在的一氧化氮合酶(NOS)催化产生的一系列高活性氮中间体,具有比反应性氧代谢物(ROM)更强的氧化与硝化活性,通过多条途径参与多种疾病的发生发展。有证据表明,RNM可能不仅参与白血病的发生发展,在白血病的治疗中也发挥不同效应,本文就RNM在白血病中的作用予以综述。Reactive nitrogen metabolites （RNM） are a series of high reactive nitrogen intermediate, which are catalyzed by nitrogen monoxidum synthase（NOS） of cells producing in metabolic process. Their reactive oxidation and nitration are more powerful than those for reactive oxygen metabolites （ROM）. RNM participate in the development of multi-species diseases by kinds of channels. It has indicated that reactive nitrogen metabolites not only participate in the development of leukemia, but also educe different effects in the therapy. This article reviewed the mnltiplicitive roles of the reactive nitrogen metabolites on leukemia.

关 键 词：反应性氪代谢物 反应性氧代谢物 自由基 微量残留白血病 

分 类 号：R552[医药卫生—血液循环系统疾病]