白细胞介素18研究进展  

Advances in the Study on Interleukin-18

作　　者：刘培华[1] 范良军[1] 

机构地区：[1]湖南省石门县人民医院神经内科,湖南石门415300

出　　处：《医学综述》2008年第13期1944-1946,共3页Medical Recapitulate

摘　　要：白细胞介素18具有多种生物学活性,能诱导Th1细胞和自然杀伤细胞产生干扰素γ,促进细胞毒T淋巴细胞和自然杀伤细胞表达FasL,增强Fas-FasL介导的细胞毒作用,有较强的抗病毒作用,并与脑损伤的免疫病理机制有一定的关系。Interleukin-18 （IL-18） has a lot of biological activities, which can induce Th 1 cells and natural ceils to produce IFN-γ, up-regulate the levels of FasL expressed by cytotoxic T ceil and natural ceils, enhance the cytotoxicity of CTL and NK mediated by Fas-FasL,and present antivirus effect stongly. In addition, IL-18 has been demonstrated to be associated with immunopathologic mechanism in brain lesions.

关 键 词：白细胞介素18 抗病毒 脑损伤 

分 类 号：R392.7[医药卫生—免疫学]