儿童铅中毒检测及干预的探讨  

Detection and intervention of lead poisoning for children

作　　者：文江舸[1] 刘艳[1] 李智永[1] 张雪娇[1] 张晓萍[2] 杜晓琳[3] 

机构地区：[1]辽宁省沈阳市儿童医院,110032 [2]辽宁省沈阳市妇幼保健所 [3]辽宁省沈阳市苏家屯妇幼保健院

出　　处：《中国妇幼保健》2008年第18期2526-2527,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨锌原卟啉(ZPP)在儿童铅中毒检测中的临床意义及补充锌、钙制剂对儿童铅中毒的治疗效果。方法:对沈阳市市属幼儿园体检中ZPP值高出正常范围的儿童进行血铅浓度检测,对其中血铅水平高出正常范围的儿童进行干预治疗,部分拒绝治疗者作为对照组,在治疗前后分别测定血铅进行对比分析。结果:ZPP值与血铅有相关性,但相关系数较低;男女儿童血铅水平有显著性差异;补充矿物质钙、锌等有助于治疗儿童铅中毒。结论:锌原卟啉测定不太适合作为儿童铅中毒的筛查方法;儿童轻度铅中毒可适当应用钙、锌等矿物质治疗。Objective： To investigate the clinical significance of zinc protoporphyrin （ZPP） in the detection of children＇s lead poisorting and the therapeutic effect of the zincic and calcic products for children＇s lead poisoning. Methods： To detect the lead level in blood for the children whose ZPP value was higher than normal value in the kindergarten affiliated to Shenyang city when they took medical examination. For those whose lead level was higher than normal value, intervention therapy was applied. Those who refused the treatment were put into control group. And the lead values in blood were compared between the two groups. Results： ZPP value was related to the lead level in blood, but the correlation coefficient was low. The therapeutic effect of zincic and calcic products was superior to the effect in control group. In addition, apparent difference of lead level in blood between boys and girls was observed. Conclusion： ZPP detel ction is not suitable for the screening of children＇s lead poisoning. Among the children with mild lead poisoning, zincic and calcic products can be recommended.

关 键 词：儿童 铅中毒 检测 防治 

分 类 号：R179[医药卫生—妇幼卫生保健]