丹参酮干乳剂的制备及体外溶出度的研究  

Preparation and dissolution in Vitro of tanshinone dry emulsions

作　　者：聂阳[1] 李苑新[1] 刘波[1] 沈嘉茵[1] 谢凯[1] 朱盛山[1] 

机构地区：[1]广东药学院中药开发研究所,广东广州510006

出　　处：《中成药》2008年第6期831-835,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金项日(30672670);"十一五"国家科技支撑计划项目(2006BAI09B08-02);广东省中医药局建设中医药强省课题(2007149)

摘　　要：目的:为提高丹参酮的溶解度,研制丹参酮干乳剂,并对其体外溶出度进行考察。方法:采用均匀设计实验,以干乳剂的外观质量、复溶效果和溶解度为评价指标,优化干乳剂支撑剂,制备丹参酮干乳剂,并进行体外溶出实验。结果:按优化支撑剂制备的干乳剂,外观质量较好;干乳剂复溶后显微观察与原乳剂相似;干乳剂丹参酮溶解度为1.305mg/mL,而丹参酮为0.024mg/mL;干乳剂体外实验120min丹参酮溶出为74.16%,而丹参酮原料的几乎不溶出。结论:丹参酮干乳剂制备工艺简单、质量稳定,能显著提高丹参酮的溶解度。AIM： To increase the solubility of tanshinone in preparation for the tanshinone dry emulsions and investigate its dissolution in vitro. METHODS： The tanshinone dry emulsions were prepared after optimizing the support agent of dry emulsions by the help of the uniform design test, using the appearance quality, redissolving effect and solubility as the evaluation index, and the dissolution test was conducted. RESULTS： The prepared dry emulsion following the optimized support agent was good in appearance quality and the appearance of its redissolving emulsion was generally paralleling with original emnlsions under the microscopic. The solubility of tanshinone in dry emulsion was 1. 305 mg/mL, which of the crude drug was 0. 024 mg/mL. The total dissolve percentage of tanshi- none from dry emulsion was 74.16 % in 120 rain test in vitro, while hardly does the crude drug perform any dissolution. CONCLUSION： The preparation of tanshinone dry emulsions is easy, stable to remarkably increase the solubility of tanshinone.

关 键 词：丹参酮 干乳剂 均匀设计 溶出度 

分 类 号：R944[医药卫生—药剂学]