丹红注射液治疗不稳定型心绞痛的临床价值  

Clinical Research of Danhong Injection for Amelioration of Microcirculation in Patients with Unstable Angina

作　　者：李昌[1] 康德[1] 吴燕生[1] 

机构地区：[1]解放军第175医院,福建漳州363000

出　　处：《临床军医杂志》2008年第3期402-404,共3页Clinical Journal of Medical Officers

摘　　要：目的观察丹红注射液对不稳定型心绞痛(UA)病人微循环的影响,及疗效、安全性、预防心血管事件发生的价值。方法将130例UA病人随机分为治疗组和对照组,对照组采用常规治疗,治疗组在常规治疗的基础上加用丹红注射液治疗,2周后比较检测两组治疗前后心绞痛疗效;常规心电图(12导联)ΣST(12导联ST压低数值总和)、血脂、血液流变学等指标的变化,血清超敏C反应蛋白(hs-CRP)并观察药物反应。结果治疗组与对照组相比,治疗组能显著改善心绞痛病人的症状(总有效率分别为93.2%与65.8%,P<0.05),改善心绞痛的缺血心电图(总有效率分别为55.3%与38.2%,P<0.05);降低纤维蛋白原浓度,降低血脂的作用也明显优于对照组(P<0.05);血液流变学检查示治疗组全血黏度、还原黏度均显著下降(P<0.05);两组患者治疗前后hs-CRP比较显示,治疗组优于对照组(P<0.05)。结论丹红注射液对UA患者的微循环指标改善明显,疗效肯定且安全。Objective To observe Danhong injection＇ s effects on the microcirculation in the patients with unstable angina （UA）. Methods A total of 130 paitents with UA were divided into trial group and control group at random. The control group was adminstered With routine treatment and the trial group with additional Danhong injection for two weeks. Results According to the comparison between the＇two groups, Danhong injection obviously eliminated the symptoms of UA （93.2% vs 65.8% in total effective rate, P 〈 0.05 ） , and improved the appearance in 12-lead electrocardiograms of UA （55.3% vs 38.2% in total effective rate, P 〈 0.05 ）. The descent of fibrinogen and lipids in blood was more obvious in the trial group than in the control （ P 〈 0105 ）, as well as the descent of blood viscosity （P 〈 0.05 ）. According to the comparison of serum hypersensitive C-reactive protein （hs-CRP） between before and after treatment, the trial group won an advantage of the control group （ P 〈 0.05 ）. Conclusion Danhong injection can improve the microcireulation in the patients with UA safely and affirmatively.

关 键 词：不稳定型心绞痛 丹红 C反应蛋自 

分 类 号：R541.4[医药卫生—心血管疾病]