海水-束缚应激大鼠血清ET和6-K-PGF1α水平的变化  

Levels of Sera ET and 6-K-PGF1α in Seawater Immersion and Restraint Stressed Rats

作　　者：施斌斌 骆益宙 

机构地区：[1]解放军454医院消化科,南京210002 [2]解放军454医院肿瘤血液科

出　　处：《华南国防医学杂志》2008年第3期17-18,共2页Military Medical Journal of South China

基　　金：南京军区医药卫生科研项目基金(06MA71)

摘　　要：目的探讨应激大鼠血清内皮素(endothelins,ET)和6-酮-前列腺素F1α(6-K-PGF1α)含量的变化与溃疡发生及程度的关系。方法选用Wistar雄性大鼠20只,平均分成2组,A组为海水-束缚应激组;B组为正常对照组。采用放射免疫法测定应激性溃疡大鼠ET和6-K-PGF1α水平,Guth法评定溃疡指数。结果A组ET水平显著高于B组(P<0.01);A组血清6-K-PGF1α水平显著低于B组(P<0.01);病理检查提示A组溃疡指数显著高于B组(P<0.01)。结论应激大鼠血清ET水平升高和6-K-PGF1α水平下降,与溃疡发生率及严重程度密切相关。Objective To detect levels of sera endothelins （ET） and 6-keto-phostaglandin F1α（6-k-PGF1α） in seawater immersion and restraint stressed rats. Methods Twenty male Wistar rats were equally divided into 2 groups. Rats in group A were stressed by seawater immersion and restraint, and group B was as a control. ET and 6-K-PGF1α in rat sera were detected by radioimmunoassay. Ulcer indexes were calculated by Guth method. Results In group A, sera ET levels were higher than those in group B （P〈0. 01） ; and sera 6-K-PGF1α levels were lower than those in group B （P〈0. 01）. Compared with group B,ulcer indexes in group A increased significantly （P〈0. 01）. Conclusion In the stressed rats higher levels of sera ET and lower level of 6-K-PGF1α were detected,and were associated with the ulcer occurrence rate and severity.

关 键 词：应激性溃疡 海水束缚应激 内皮素 6-K-PGF1Α 

分 类 号：R825.7[医药卫生—临床医学]