Cx43、同型半胱氨酸与先天性心脏病  

Cx43,Homocysteine and Congenital Heart Defect

作　　者：王海琴[1] 王新[1] 

机构地区：[1]中南大学湘雅二医院妇产科

出　　处：《中国分子心脏病学杂志》2008年第3期182-186,共5页Molecular Cardiology of China

摘　　要：先天性心脏病是常见的新生儿先天性畸形。心脏发育涉及一系列细胞增殖、迁移、分化和形态发生相关的因子的作用。间隙连接蛋白43是哺乳动物心脏中最主要的连接蛋白,对心脏发育有重要作用。高同型半胱氨酸血症是一个独立的发育潜在致畸因子,能诱发先天性心脏病。研究发现Cx43基因缺陷及高同型半胱氨酸血症与其发生密切相关。Congenital heart defect（CHD） is a frequent congenital abnormality in neonatus. Mostly, it results from a complex mixture of environmental and genetic factors. Cardiogenesis requires a complex process of events including proliferation, migration, differentiation and morphogenetic interactions involving cells from several embryonic origins. A great deal of genes function and interact in the complex process. Gap junction channels formed by connexin43 （ Cx43 ） protein are important in cardiac morphogenesis and Cx43 gene is thought to be associated with CHD. High density of homolysteine is an independent clastogenic factor and can deduce CHD. Recent work has elucidated that Cx43 gene defect and hyperhomocystinemia closely correlates with CHD. we review the relation between Cx43 gene defect ,homocysteine and CHD respectively.

关 键 词：先天性心脏病 CX43 同型半胱氨酸 心脏发育 

分 类 号：R541.1[医药卫生—心血管疾病]