灯盏花素对D-半乳糖引起小鼠记忆障碍的改善作用  

Improving Effects of Breviscapine on Memory Deficites Induced by D-galactose in Mice

作　　者：石艳华[1] 缪红[1] 苏丙凡[1] 程建军[1] 商亚珍[1] 

机构地区：[1]承德医学院,河北承德067000

出　　处：《时珍国医国药》2008年第6期1445-1446,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的研究灯盏花素对D-半乳糖引起小鼠衰老的改善作用。方法小鼠腹腔注射120mg／kg D-半乳糖48d制备衰老模型，通过小鼠学习／记忆能力及胸腺、脾脏和睾丸的脏器指数的测定，评价灯盏花素对D-半乳糖引起小鼠衰老的作用。结果D-半乳糖明显引起小鼠衰老症状，与空白对照组相比，D-半乳糖组小鼠（120mg／kg，ip，47-48d）学习／记忆能力显著降低，胸腺、脾脏和睾丸的脏器指数也明显异常改变。5，10和20mg／kg灯盏花素不同程度地改善D-半乳糖引起小鼠上述衰老症状。结论灯盏花素对D-半乳糖引起小鼠学习记忆障碍有明显的改善作用。Objective To study the improving effects of breviscapine （Bre） on aging induced by D - galactose in mice. Methods The aging model of mice was made by introperitoneal injection of 120 mg/kg D - galactose for 48 d, The anti- aging effects of Bre were evaluated by the learning and memory ability, thymus,spleen and testicle index measurements, Results D -galactose（ 120 mg/kg, ip, 47 -48 d） significantly resulted in the senescent symptoms in mice, Compared with control group, the D -galactose mice could decrease learning and induce the memory ability, and induce the abnormal changes of thymus, spleen and testicle index. 5, 10 and 20 mg/kg Bre significantly improved the above abnormal alterations in different degree induced by D - galactose. Conclusion Bre has significant improving effects on memory deficits induced by D - galactose in mice.

关 键 词：灯盏花素 D-半乳糖 衰老 记忆障碍 

分 类 号：R285.5[医药卫生—中药学]