黄芪皂苷和黄芪多糖对大鼠肾脏系膜细胞增殖的影响  

Effect of Astragalosides and Astragalus Polysaccharide on the Proliferation of Glomeruli Mesangial Cells

作　　者：房信胜[1] 穆象山 周红英[1] 王建华[1] 谭晓梅[3] 

机构地区：[1]山东农业大学农学院,山东泰安271018 [2]山东省泰安市中医医院,271000 [3]南方医科大学,广东广州510515

出　　处：《时珍国医国药》2008年第6期1448-1449,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察黄芪皂苷和黄芪多糖对体外培养的肾脏系膜细胞增殖的影响。方法分离和培养大鼠肾脏系膜细胞,用MTT法研究不同浓度的皂苷和多糖对细胞增殖的影响,并计算抑制率。结果黄芪多糖在低浓度时表现出一定的促进细胞增殖作用,在高浓度时有一定的抑制作用;黄芪皂苷在所考察的范围内均表现出一定的抑制作用。结论黄芪皂苷和黄芪多糖在一定浓度时对肾脏系膜细胞增殖具有一定的抑制作用,为其在治疗肾小球肾炎中的作用提供了理论依据。Objective To study the effect of Astragalosides and Astragalus Polysaccharide on the proliferation of glomeruli mesangial cells（GMCs）. Methods Extract and culture GMCs from SD rats,then study the effect of different density of Astragalosides and Astragalus Polysaccharide on the proliferation of GMCs by MTT assay, and calculate the inhibitory rate. Results Astragalus Polysaccharide could stimulate the cells to reproduce in low density, and had inhibitory activity in high density. Astragalosides show some inhibitory activity in the density investigated. Conclusion Astragalosides and Astragalus Polysaccharide can inhibit proliferation of GMCs.

关 键 词：黄芪皂苷 黄芪多糖 肾脏系膜细胞 增殖 

分 类 号：R962[医药卫生—药理学]