同型半胱氨酸水平与老年冠心病患者颈动脉内-中膜厚度的相关性  

Relationship between serum homocysteine and carotid artery intima -media thickness in the aged patients with coronary heart disease.

作　　者：赵娅 张书富[2] 徐惠芬[3] 杜月芳 Zhao Ya ,Zhang Shufu ,Xu Huifen ,et al. （ Department of cardiology ,Kongjiang Hospital of Yangpu District ,Shanghai 200093 China）

机构地区：[1]上海市杨浦区控江医院,上海200093 [2]上海市杨浦区中心医院 [3]上海市新华医院

出　　处：《中国保健》2008年第18期759-761,共3页Chinese Health Care

摘　　要：目的：观察老年冠心病患者血清同型半胱氨酸（Hcy）水平与颈总动脉内-中膜（IMT）厚度的相关性。方法：对72例冠心病老年患者测定血清Hcy水平，并同时做颈动脉超声检查，以颈总动脉IMT有无增厚作为分组标准。其中颈总动脉IMT增厚组48例，非增厚组24例，两组进行性别、年龄、Hcy、TC、TG、LDL、HDL、高血压病患病率、2型糖尿病患病率比较，并对颈总动脉IMT增厚组中各危险因素进行多元逐步回归分析。结果：颈总动脉IMT增厚组血清Hcy水平、Tc水平、高血压病患病率高于非IMT增厚组，两组差异显著（P〈0．05），经多元逐步回归分析后自变量Hcy及LDL对颈动脉IMT增厚有显著影响，为独立危险因素。结论：高Hcy是导致老年冠心病患者颈动脉IMT增厚的一个独立危险因素，与动脉粥样硬化密切相关。Objective：To investigate the relationship between serum homocysteine levels and carotid intima - media thickness in the aged patients with coronary heart disease. Methods ： The serum Hcy level of 72 aged patients and the serum lipids were measured at the same time. All patients underwent ultrasound examinations the IMT of carotid arteries. We classified them as IMT increased group （n = 48） or no IMT increased group （n = 24）. The data comparison was made. Results：There were significant different（P 〈 0. 05 ） in Hcy, LDL, the rate of hypertensives between two groups. Multiple regression analysis showed that Hcy and LDL were the independent factors of carotid artery intima - media thickness increase. Conclusion：Higher serum Hcy is a independent risk factor for carotid artery IMT increased of aged patients with CHD.

关 键 词：同型半胱氨酸 颈动脉内-中膜厚度 冠心病 老年人 

分 类 号：R541.4[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]