p75基因与2型糖尿病大鼠脑细胞凋亡相关性研究  

Relationship between Expression of p75 Gene and Apoptosis of Cerebrum Cells in Type 2 Diabetic Rats

作　　者：任凤云[1] 宗灿华[1] 吕秀芳[1] 郭新民[1] 

机构地区：[1]牡丹江医学院生物化学与分子生物学教研室,黑龙江牡丹江市157011

出　　处：《中国康复理论与实践》2008年第6期533-534,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨2型糖尿病大鼠p75基因表达与脑细胞凋亡的关系。方法选取2型糖尿病大鼠及正常对照组大鼠各10只,采用RT-PCR法检测脑组织p75基因mRNA表达,琼脂糖凝胶电泳检测细胞凋亡。结果2型糖尿病大鼠P75基因mRNA表达上调,且脑组织细胞凋亡明显增加。结论2型糖尿病大鼠脑组织细胞凋亡增加,与p75基因表达呈正相关。Objective To study the relationship between expression of p75 gene and apoptosis of cerebrum cells in type 2 diabetic rats. Methods Ten type 2 diabetic rats and ten natural rats were used to test the expression of brain p75 mRNA by RT-PCR technique, and the apoptosis of cerebrum cells was measured by agarose gel electrophoresis （AGA）. Results The expression of brain p75 mRNA and apoptosis of cerebrum cells in type 2 diabetic rats were higher than that of the natural group. Conclusion The apoptosis of cerebrum cells in type 2 diabetic rats increases, and it is positively correlated with the expression of brain p75 gene mRNA.

关 键 词：2型糖尿病大鼠 p75基因 细胞凋亡 

分 类 号：Q255[生物学—细胞生物学]