不育男性精浆锌与精子密度、形态及运动性关系探讨  

Study on relations of seminal plasma Zinc concentration and sperm concentration,morphology and motility

作　　者：李付彪[1] 郭淑英[2] 许宗革[3] 刘祥印[3] Binay 刘睿智[3] 

机构地区：[1]吉林大学第一医院泌尿外科,吉林长春130021 [2]吉林医药学院,吉林吉林132013 [3]吉林大学白求恩医学院细胞生物学教研室吉林省生殖医学研究所,吉林长春130021

出　　处：《中国现代医学杂志》2008年第11期1594-1597,共4页China Journal of Modern Medicine

基　　金：吉林省科技厅资助项目(200505140)

摘　　要：目的探讨不育男性精浆锌与精子密度、形态及运动性的关系。方法分析87例男性不育患者精液样本,采用计算机辅助精液分析进行精液参数检测,采用精子形态检测系统下人工修正方法进行精子形态分析,采用分光光度比色法测定精浆锌含量。结果不育男性精浆锌含量与精子密度之间有显著的正相关性(r=0.355,P<0.05),与MAD和BCF之间有显著的正相关性(r分别为0.232和0.266,P<0.05),而与精子活力、精子形态之间差异没有显著性关系(P>0.05)。密度异常组精浆锌含量显著低于密度正常组和生育组(P<0.01)。活力异常组精浆锌含量与活力正常组和生育组比较差异均无显著性(P>0.05)。形态异常组精浆锌含量与形态正常组、生育组比较差异均无显著性(P>0.05)。结论精浆锌含量降低能使精子密度下降,但对精子活力和形态没有显著影响。[Objective] To study the relationship between seminal plasma Zinc concentration and sperm concentration, morphology and motility. [Methods] Sperm samples were obtained from 87 patients of male infertility. Semen parameters were detected by computer assisted sperm analysis （CASA）. The sperm morphology analysis using semiautomatic sperm morphology analyzer was performed. Seminal plasma Zinc concentration was measured by spectrophotometer. [Results] A significant positive correlation was observed between seminal plasma Zinc concentration and sperm concentration （r =0.355, P 〈0.05）. Zinc levels and MAD, BCF have significantly positive correlation （r=0.232, 0.266, P 〈0.05, respectively）. There was no significantly negative correlation between seminal plasma Zinc concentration and sperm morphology, motility （P 〉0.05）. Zinc levels of abnormal group of sperm concentration was significantly lower than that of normal group and fertile group （P〈0.01）. There were no different Zinc levels among different motility and morphology groups （P〉0.05）. [Conclusion] Low Zinc concentration in seminal plasma is apparently related to low sperm concentration in infertile patients. Zinc levels in seminal plasma don＇t influence sperm motility and morphology.

关 键 词：男性不育 精浆锌 精子密度 精子活力 精子形态 

分 类 号：R698.2[医药卫生—泌尿科学]