嵌段共聚物核交联胶束的制备与载药性能研究  

Preparation of amphiphilic diblock copolymer core cross-linked micelles and using as drug carrier

作　　者：郭艳玲[1] 赵军[2] 左榘[1] 韩聪[3] 

机构地区：[1]南开大学化学学院,天津300071 [2]天津科技大学材料科学与化学工程学院,天津300457 [3]天津科技大学理学院,天津300457

出　　处：《化学研究与应用》2008年第6期724-728,共5页Chemical Research and Application

基　　金：天津市高等学校科技发展基金项目(020908)

摘　　要：在DMAP的催化和DIPC的作用下,丙烯酸的双键被引入聚乙二醇-聚己内酯嵌段共聚物的疏水链段上,制备胶束过程中使用过硫酸铵催化位于胶束内核部分的双键交联,得到的核交联胶束。在包载甲氨喋呤释放过程中,核交联胶束的累积释放率明显比非核交联胶束的小,具有良好的缓释效果。The double bonds of acrylic acid were joined on the hydrophobic block of poly（ ethylene glycol）/poly（e-caprolactone） diblock eopolymer under the catalysis of DMAP. The double bonds in the core of micelles were cross-linked by the initiation of （NH4） 2S2O8 during the micelles formed. Comparing with noncross-linked micelles, the accumulated release amount of MTX in cross-linked micelles is much lower. The core cross-linked mieelles perform well in drug controlled releasing.

关 键 词：胶束 核交联 药物控制释放 

分 类 号：O631.4[理学—高分子化学]