生姜的丙酮提取物对大鼠异嗜高岭土模型的止呕作用  

作　　者：张来银[1] 

机构地区：[1]山东省临沂市人民医院药学部,276000

出　　处：《中国医药指南（学术版）》2008年第9期23-26,共4页Guide of China Medicine

摘　　要：目的研究生姜丙酮提取物(EG)对大鼠的止呕作用。方法大鼠分别给予不同剂量的顺铂、阿朴吗啡及接受旋转刺激,建立大鼠异嗜高岭土的3种呕吐模型。观察EG预防给药对3种模型大鼠的止呕作用。结果顺铂(3mg/kg,ip)、阿朴吗啡(3.2mg/kg,sc)以及旋转刺激(100 r/min,1h)均能引起大鼠的异嗜行为,可作为建立大鼠异嗜高岭土模型的最适剂量。EG600、300、150mg/kg三个剂量组可抑制顺铂、阿朴吗啡、旋转所致的大鼠异嗜高岭土的量(P<0.05 P<0.01),并呈现一定的量效关系。结论EG在大鼠异嗜呕吐模型上具有止呕作用,其机制可能与P物质、5-HT及抑制呕吐中枢有关。Objective To study the antiemetic effects of extract of ginger（EG） in rats. Methods The rats were randomly divided into groups and administrated with cisplatin, apomorphine and rotation respectively, three kinds of kaolin pica models were made in rats for observing the antiemetic effects of EG by preadministration. Results The emetic model in rats was successfully established by cisplatin （3 mg/kg, ip）, apomorphine （3.2 mg/kg ,sc） and rotation （100 r/min,1h）, EG inhibited kaolin intake which induced by cisplatin, apomorphine and rotation in a dose-dependent manner （P〈0.05）. Conclusion The EG exhibits a antiemetic effects in rats,which may be mediated by inhibiting substance P, 5 HT and the vomiting center in central nervous system.

关 键 词：生姜 止呕 P物质 5-HT 大鼠 

分 类 号：R285.5[医药卫生—中药学]