大蒜油口腔黏附片的研究  

Investigation of Garlic Oil Buccal Adhesive Tablets

作　　者：上官盈盈[1] 俞佳[2] 富丽慧[3] 马珂[2] 

机构地区：[1]浙江医学高等专科学校药学系,杭州310053 [2]浙江省人民医院药剂科,杭州310014 [3]浙江大学城市学院,杭州310015

出　　处：《中国现代应用药学》2008年第3期213-217,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省教育厅科研计划项目(编号:20050341)

摘　　要：目的研制大蒜油口腔黏附片,并考察其生物黏附性及释药性能。方法采用羟丙基甲基纤维素(HPMC)和卡波姆(Carbopol 934P)为黏附材料,制备不同处方配比的大蒜油口腔黏附片,测定其体外溶胀百分率、黏附力和黏附时间,并采用浆法测定释放度。结果以HPMC:Carbopol 934P为3:1的处方制得的口腔黏附片较好。结论成功制备了大蒜油口腔黏附片。OBJECTIVE To prepare Garlic Oil buccal adhesive tablets and to observe the bioadhesive properties and drug release performance. METHODS The Garlic Oil buccal adhesive tablets were prepared using hydroxy-propyl methyl cellulose （HPMC） and carbomer（ Carbopol 934P） with different proportion, and the swelling percent, adhesive force and adhesive time in vitro of which were determined. The release of Garlic Oil buccal adhesive tablets was determined by HPLC according to the paddle method. RESULTS The Garlic Oil buccal adhesive tablets prepared by Carbopol 934P and HPMC with 1：3 were of the best outcome. CONCLUSION The Garlic Oil buccal adhesive tablets were prepared successfully.

关 键 词：大蒜油 口腔粘附片 生物粘附 

分 类 号：R944.4[医药卫生—药剂学] R988.2[医药卫生—药学]