六种中草药注射液配伍葡萄糖注射液后对输液质量的影响  

Study on the Quality of Glucose Injection after Matching with Six Chinese Materia Medical Injection

作　　者：李建凯[1] 李莉[1] 赵元文 崔秀芸 

机构地区：[1]长庆石油勘探局职工总医院,甘肃庆阳745101

出　　处：《中国现代应用药学》2008年第3期255-258,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的观察六种中草药注射液配伍葡萄糖注射液(250 mL∶12.5 g)后对输液质量的影响情况。方法利用药典规定的方法和标准,在配伍前和配伍后的不同时间对输液中不溶性微粒等四项主要指标进行测定。结果参麦和黄芪注射液的四项指标全部合格,其余品种配伍后不合格的主要项目是不溶性微粒(≥10μm)超标。结论建议中草药注射液质量标准中增加不溶性微粒的监测,加大不同规格中草药输液的开发。OBJECTIVE To observe the quality of Glucose Injection（250 mL： 12.5 g） after matching with six Chinese materia medical injection. METHODS The change of matching infusion in insoluble particulate matter, pH, endotoxin and appearance were determined by method of pharmacopeia. RESULTS Except for matching infusion of Huangqi injection and Shenmai injection, the additional two matching infusion in six Chinese materia medical injection are not qulified, It is the important problem that insoluble particulate matter（≥10 μm） in infusion which are superstandard after matching medicines. CONCLUSION It is suggested that the monitor of insoluble particulate matter be added in qulity standard and the large volume influsion be developed for Chinese materia medical injection.

关 键 词：中草药注射液 不溶性微粒 葡萄糖注射液 配伍液 

分 类 号：R969.2[医药卫生—药理学] R285.6[医药卫生—药学]