麟生颗粒的制备及质量控制  

Preparation and Quality Control of Linsheng Granules

作　　者：应海燕[1] 沈国兴 张宇燕[3] 李金辉[3] 

机构地区：[1]杭州市上城区中西医结合医院,杭州310008 [2]浙江省青春医院,杭州310016 [3]浙江中医药大学心脑血管病研究所,杭州310053

出　　处：《中国现代应用药学》2008年第3期260-262,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的制备麟生颗粒并建立质量控制标准。方法对麟生颗粒中的主要成分淫羊藿、仙茅进行了薄层色谱定性鉴别；用高效液相色谱法对淫羊藿苷进行含量测定。结果薄层鉴别方法专属性强。淫羊藿苷在1．1～20．9μg·mL^-1内有良好的线性关系。回归方程Y=43857X-5324．2（r=0．9999），平均回收率为98．28％，RSD为2．39％。结论本法操作简便、准确、分离效率高、稳定性好、分析速度快，为本制剂的质量控制提供了可靠的方法。OBJECTIVE To prepare Linsheng Granules and establish the quality control standards. METHODS The main ingredients of Linsheng Granule ： Epimedium and Baking were identified by TLC ; HPLC was used to determinate the content of Icariin. RESULTS TLC method was highly specific. The Iinearity of Icariin was in the range of 1. 1 - 20.9 μg · mL^ - 1. The regression equation was Y = 43 857X- 5 324. 2 （r = 0. 999 9） ,The average recovery was 98.28% and RSD was 2.39%. CONCLUSION The method is simple,accurate,reliable and rapid,and can be applied to the quality control of Linsheng Granule.

关 键 词：麟生颗粒 制备工艺 质量控制 

分 类 号：R931.6[医药卫生—生药学] R917.4[医药卫生—药学]