大鼠纹状体GABA受体的表达及年龄性变化  

AGED-RELATED CHANGES IN THE EXPRESSION OF GABA RECEPTOR OF RAT STRIATUM

作　　者：彭建安[1] 郭萍[1] 瘳家万[1] 王芳[2] 刘向前[2] 王小丽[2] 刘胜洪[2] 

机构地区：[1]江西井冈山大学医学院解剖学系,江西343300 [2]华中科技大学同济医学院基础医学院组织胚胎学教研室,武汉430030

出　　处：《中国组织化学与细胞化学杂志》2008年第3期323-326,共4页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：目的观察大鼠纹状体GABA受体的表达特征及增龄性变化。方法应用免疫组织化学及图像分析,Western blot观察大鼠纹状体GABARa受体的表达及年龄相关性变化。结果随着年龄的增加,大鼠纹状体GABAR阳性神经元及纤维明显增加,神经纤维排列紊乱,GABA免疫反应明显增强。结论老龄大鼠纹状体神经元GABAR的表达增加可能是一种有规律的增龄性变化。老年机体的某些抑制性精神症状可能与之有关。Objective To observe the aged-related changes in the expression of GABA receptor of rat striatum. Methods Immunocytochemistry and Western blot were used to detect the expression and age-related change of GABAR in striatum. Results The number of GABAR positive neuron and nerve fibers were gradually increased in the striatum of rats from young to old age. GABAR positive fibers were distributed disorderly and intensity of GABAR immunohistochemistry was also increased with age. Conclusion The age-related increase of GABAR expression in striatum of rats may be a regular change. It may be related with some mental disorder of old rats.

关 键 词：γ氨基丁酸受体A 纹状体 神经元 老化 

分 类 号：R37[医药卫生—病原生物学] R339.38[医药卫生—基础医学]