泮托拉唑联合格拉司琼防治化疗所致消化道反应的临床观察  

Clinical Study of Pantoprazole Combined with Granisetron on Prevention and Cure of Alimentary Toxicities Caused by Tumor Chemotherapy

作　　者：李道俊[1] 许新华[2] 文彩虹[3] 薛峰[2] 彭绪申[2] 张小红[1] 

机构地区：[1]三峡大学第一临床医学院,湖北宜昌443003 [2]宜昌市中心人民医院肿瘤科 [3]三峡大学肿瘤研究所

出　　处：《肿瘤防治研究》2008年第6期439-441,共3页Cancer Research on Prevention and Treatment

摘　　要：目的观察泮托拉唑与格拉司琼+地塞米松联用治疗肿瘤化疗所致消化道反应的疗效和不良反应。方法将125例化疗所致难治性呕吐的病人随机分为两组,在下一周期化疗中泮托拉唑组予泮托拉唑+格拉司琼+地塞米松,对照组予格拉司琼+地塞米松,比较两组的临床效果与药物不良反应。结果泮托拉唑组在预防食欲不振、抑制恶心、呕吐等方面明显优于对照组,差异有统计学意义(P值均<0.05);两组头晕、腹痛、便秘、乏力、颜面潮红、失眠等不良反应发生率相仿,差异无统计学意义(P值均>0.05)。结论泮托拉唑联合格拉司琼防治化疗药物所致消化道反应疗效较好,值得临床推广应用。Objective To investigate the curative and adverse effects of pantoprazole combined with granisetron for alimentary toxicities caused by tumor chemotherapy. Methods One hundred and twenty-five cases involved in intractable vomiting caused by tumor chemotherapy were divided into two groups at random on the second chemotherapy cycle. Sixty-four patients of pantoprazole group were treated with pantoprazole ＋ granisetron ＋ dexathasone , and sixty-one ones of control group were treated with granisetron ＋ dexathasone. Results Pantoprazole group was superior to control group in the prevention of appetite loss, nausea and vomiting with significant difference （P〈0. 05）. Side-effects such as headache, stomachache, constipation, acratia, blushing, insomnia were similar（P〉0. 05）. Conclusion Pantoprazole combined with granisetron is a good choice in prevention of alimentary toxicities caused by tumor chemotherapy and worth extending its clinical application.

关 键 词：泮托拉唑 格拉司琼 化疗 消化道反应 

分 类 号：R975.2[医药卫生—药品] R730.53[医药卫生—药学]