生物法生产2，3-丁二醇研究进展  

Research Progress of 2,3-butanediol Production by Biological Method

作　　者：张刚[1] 杨光[2] 李春[1] 裴海生[1] 曹竹安[2] 

机构地区：[1]石河子大学食品学院,石河子832003 [2]清华大学化学工程系生物化工研究所,北京100084

出　　处：《中国生物工程杂志》2008年第6期133-140,共8页China Biotechnology

基　　金：国家“973”计划(2007CB707800);国家“863”计划(2006AA02Z237)、资助项目

摘　　要：2,3-丁二醇是一种重要的化工原料,可广泛应用于多个领域。二战期间由于合成橡胶需要大量1,3-丁二烯,2,3-丁二醇生产空前发展。近年来,由于聚对苯二甲酸丁烯树脂、γ-丁内酯,Spandex弹性纤维及其前体的需求增长,2,3-丁二醇的需求和产量也稳步增长。多年来,生物法生产2,3-丁二醇虽然得到了广泛的研究,但一直没有实现工业化。从产生2,3-丁二醇的菌种及2,3-丁二醇的生理意义、代谢途径、旋光异构体的形成机理、影响发酵的因素与产物的提纯等方面对生物法生产2,3-丁二醇进行了综述并提出了生物法生产2,3-丁二醇要解决的几个问题。2,3-butanediol （2,3-BD） is an important chemical intermediate and can be used in many fields. 2,3-BD production come to a peak during World War I1 because 1,3-butanediene used for synthetic rubber production could be made from 2,3-BD. Due to the increased demand for polybutylene terephthalate resin, gamma-butyrolactone,spandex and their precursors,the demand and yield of 2,3-BD increased stably in recent years. Although 2,3-BD production by fermentation has been studied widely for many years, its industrialization did not realized till now. The microbe species and the physiological function of 2,3-BD to cell, metabolic pathway, mechanism of stereoisomers formation ,the factors influencing the fermentation and downstream recovery of 2,3-BD is discussed ,and some problems should be solved in 2,3-BD production is also presented.

关 键 词：2 3-丁二醇 生物法 旋光异构体 氧气 PH 

分 类 号：TK6[动力工程及工程热物理—生物能] TQ517[化学工程]