何首乌对衰老大鼠学习记忆能力和海马超微结构的影响  

The Ifluence of Radix Polygonum Multiflorum on the Hippocampus Ultrastructure in the Senile Rat

作　　者：李怡秋[1] 谭红[1] 李芳芳[1] 马俊骥[1] 

机构地区：[1]河北省石家庄市疾病预防控制中心,050011

出　　处：《职业与健康》2008年第14期1391-1392,共2页Occupation and Health

摘　　要：目的探讨何首乌对衰老大鼠海马超微结构的影响。方法给大鼠注射大剂量D-半乳糖(D组),通过行为学测试,电子显微镜形态学观察,观测大鼠学习记忆能力和海马超微结构的变化。结果与对照组(C组)比较,D-半乳糖组大鼠逃避潜伏期延长,海马组织超微结构发生病理改变,何首乌组(H组)逃避潜伏期与对照组比较,差异无统计学意义,海马超微结构轻度病理改变。结论何首乌能够改善D-半乳糖引起的海马超微结构损害,对D-半乳糖引起的记忆力下降有预防作用。[ Objective] Explore the influence of radix polygonum multiflorum on the hippoeampus ultrastructure in the senile rat. [ Methods] Rats were injected with D-galactose, then measured the ability of learning and memory in Morris water maze, observed the changes of hippocampus ultrastructure on electron transmission microscope. [ Results] The escape latency of D group is longer than C group（ P 〈0.05） ,and there was no difference between H group and C group（ P 〉 0. 05）. Electron microscope demonstrated that rats in D group had remarkable aging characteristics, the condition of H group was better than D group. [ Conclusion ] It suggested that radix polygonum multiflorum could improve the damage of hippocampus ultrastructure and delay the senescence induced by D-galaetose.

关 键 词：学习记忆 大鼠 D-半乳糖 衰老 何首乌 

分 类 号：R285.5[医药卫生—中药学]