白大衣高血压血管紧张素转换酶基因多态性分析  

Analysis of the distribution of angiotensin converting enzyme gene I/D polymorphism in patients with white coat hypertension

作　　者：周建光[1] 刘长云[1] 方以群[2] 周颖奇[1] 黄亚莉[1] 

机构地区：[1]解放军第411医院,上海市200081 [2]解放军海军医学研究所

出　　处：《心血管康复医学杂志》2008年第3期211-213,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究白大衣高血压与血管紧张素转换酶(angiotensin converting enzyme,ACE)基因Ⅰ/D多态性的关系。方法:应用多聚酶链式反应(PCR)方法对白大衣高血压,高血压病Ⅰ级患者和正常血压者各30例进行ACEⅠ/D基因型检测,并分析比较。结果:白大衣高血压和高血压病Ⅰ级组II基因型低于正常组(P<0.01),白大衣高血压和高血压病Ⅰ级组DD基因型高于正常组(P<0.01),白大衣高血压ID基因型显著高于高血压病Ⅰ级组和正常组(P<0.01)。高血压病Ⅰ级组ID基因型低于正常组(P<0.01)。结论:白大衣高血压与ACE基因多态性有关,ID基因型者易患白大衣高血压。Objective： To observe the distribution of angiotensin converting enzyme （ACE） gene I/D polymorphism in patients with white coat hypertension （WCH）. Methods： Polymerase chain reaction （PCR） technique was used to detect the ACE gene I/D polymorphism in 30 WCH patients, 30 patients with essential hypertension （EH） grade Ⅰ and 30 normal blood pressure （BP） controls and further restriction analysis was performed. Results： The Ⅱ genotype in WCH group and EH grade Ⅰ group was significantly lower than that in control group （P〈0.01）. The DD genotype in WCH group and EH grade 1 group was significantly higher than that in control group （P〈0.01）. The ID genotype in WCH group was significantly higher than that in control group and EH grade Ⅰ group （P%0.01 ）. The ID genotype in EH grade Ⅰ group was significantly lower than that in control group （P〈0.01）. Conclusion： The White coat hypertension is associated with ACE I/D polymorphism. The subjects with the character of ID genotype are at higher risk of white coat hypertension.

关 键 词：白大衣高血压 肽基二肽酶A 基因 

分 类 号：R544.109[医药卫生—心血管疾病]