蔗糖诱发Sprague-Dawley雄性大鼠肥胖病高脂血症  

The Obesity and Hyperlipemia Induced by Sucrose in Sprague-Davley Male Rats.

作　　者：邵淑丽[1] 徐兴军[1] 夏建润[1] 魏开元[2] 

机构地区：[1]齐齐哈尔师范学院生物系 [2]北京师范大学生物系

出　　处：《生物技术》1997年第6期30-33,共4页Biotechnology

摘　　要：用蔗糖作辅助铁水，饲养刚离乳的Sprague－Dawley雄性大鼠，180天后，53％大鼠肥胖成为饮食诱发肥胖型大鼠（DIO大鼠），47％大鼠不肥胖成为饮食诱发肥胖抵抗型大鼠（DIO－R大鼠）且DIO和DIO－R大鼠均具高脂血症。说明25％蔗糖可诱发Sprague-Dawley雄性大鼠肥胖病高脂血症，但同样条件下为什么部分大鼠不肥胖还有待于进一步研究。另外，对DIO大鼠的肥胖机制作了初步探讨。Timed wealing Sprague-Lhaler male rats had been drinking sucrose solution adlibitum be-sides water and food an libitum for 180 days. 53 Percent rats became dietary induced obesity(DIO) and 47 Percent rats became dietary induced obesity resistance (DIO-R). There were hy-perlipemia in dietary induced obesity and dietary induced obesity resistance rats. Suggesting thatdietary induced obesity rats with hyperlipemia were successfully made by using 25 percent sucrosesolution as auxiliary drinking-water. Moremover, The mechanism of dietary induced obesity inrats were investigated.

关 键 词：肥胖病 高脂血症 病理 蔗糖 动物实验 

分 类 号：R589.202[医药卫生—内分泌]