BRDⅡ株风疹减毒活疫苗免疫持久性观察  

Immunopersistent of Attenuated Live Rubella Vaccine Prepared with BRD Ⅱ Strain

作　　者：王淑珍[1] 韩雅儒[1] 王长太[1] 董春明[1] 华伟湘 杜方众 张光荣 胡洪江 李爱云 李跃华 

机构地区：[1]卫生部北京生物制品研究所,北京100024 [2]湖南省常德地区卫生防疫站,常德415000 [3]湖南省常德市卫生防疫站,常德41500

出　　处：《中国生物制品学杂志》1997年第4期247-249,共3页Chinese Journal of Biologicals

摘　　要：应用BRDⅡ株26代、28代和31代风疹减毒活疫苗对风疹血凝抑制（HI）抗体阴性的551名1～6岁儿童进行了免疫效果观察。3批疫苗免局42天抗体阳转率分别为98．0％、96.8％和96.4％，抗体GMT分别为115.1、100.9和94．8，表明BRDⅡ株具有良好的免疫原性。3批疫苗的抗体GMT逐年下降，到第3年分别为34、4、36．9和31．2，但各批间差异无显著意义。免后3年，26代和28代疫苗的抗体阳性率仍保持在95％以上，而31代疫苗的抗体阳性率下降至89．2％，明显低于其它两批疫苗。551 children (aged 1~6 years) without HI antibodies to rubella were inmmunized with 3 lots of attenuated live rubella vaccines prepared with the 26th, 28th and 31th passage of BRD Ⅱ strain respectively. The HI antibody positive conversion rates of the children 42 days after being immunized with the 3 lots were 98.0%, 96. 8% and 96. 4%respectively, and the GMTs of them were 115. 1, 100.9 and 94. 8 respectively. The result showed good immunogenicity of BRDⅡ strain. The GMTs were decreased from year to year. They were 34. 4, 36. 9 and 31. 2 respectively at the 3rd year after immunization. However, no significant difference was found among the GMTs of the 3 lots. At the 3rd year,the antibody positive rates of the vaccines prepared with the 26th and 28th passage of BRD Ⅱ strain were still above 95%, but that of the vaccine prepared with the 31th passage was decreased to 89. 2 %, that was signficantly lower than those of the other 2 lots.

关 键 词：风疹 风疹减毒活疫苗 免疫原性 免疫持久性 

分 类 号：R511.203[医药卫生—内科学] R392－33[医药卫生—临床医学]