神经元的迁移机制  

Mechanism of Neuronal Migration.

作　　者：于文斗[1] 张锦珠[1] 

机构地区：[1]中国科学院生物物理研究所,北京100101

出　　处：《生物化学与生物物理进展》1997年第6期499-504,共6页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目!(39370 193)

摘　　要：在脊椎动物的脑发育过程中 ,未成熟的神经元在时间和空间上的精确迁移到达最后行使功能的目的地 ,是中枢神经系统发育的一个重要阶段 .最近的研究结果表明这一过程涉及到一系列分子事件 ,包括细胞表面分子的相互作用、离子通道的激活和细胞骨架的作用等 .对这些事件的了解不但有助于了解神经元迁移的机制 。During development of central nervous system(CNS) of vertebrate, immature neurons migrate from the place of their proliferative zone to the final destination to exert their function. The neuronal migration with precise temporal and spatial pattern has been viewed as a discrete step in CNS development. Recent studies have shown that this process involves cooperation of a series of molecular events, including interactions of cell adhesive molecules, activation of ion channels, and organization of cytoskeloton. Therefore, it is important not only in elucidating the mechanism of neuronal migration, but also in gaining a new insight into the pathogenesis of brain disorders caused by defective neuronal migration to understand these events.

关 键 词：神经元 神经胶质细胞 迁移 

分 类 号：Q422[生物学—神经生物学]