内侧颞叶癫痫与人类疱疹病毒-6型的相关性  

Relationship between mesial temporal lobe epilepsy and human herpesvirus-6

作　　者：于臻[1] 孙若鹏[1] 

机构地区：[1]山东大学齐鲁医院小儿内科,济南250012

出　　处：《山东大学学报（医学版）》2008年第5期531-534,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨内侧颞叶癫痫与人类疱疹病毒-6(HHV-6)感染的关系。方法利用PCR技术检测HHV-6在27例难治性癫痫脑组织和血标本中的感染情况。其中,内侧颞叶癫痫(MTLE)15例,其他类型难治性癫痫(non-MTLE)12例,并用20例无癫痫病史的脑肿瘤周围正常脑组织和外周血作为对照。结果HHV-6 DNA在难治性癫痫患者脑组织中的阳性率为44.4%。其中,15例MTLE组患者脑组织中10例阳性,阳性率为66.7%;而在12例其他类型难治性癫痫中仅2例阳性,阳性率为16.7%;对照组均显示阴性。血标本显示MTLE 11例、非MTLE 3例、对照组1例阳性。结论难治性癫痫,尤其是内侧颞叶癫痫与人类疱疹病毒-6感染具有明确的相关性。Objective To investigate the correlation between human herpesvirus-6 （HHV-6）infection and mesial temporal lobe epilepsy（MTLE）. Methods 27 patients with intractable epilepsy and 20 normal controls were determined HHV-6 using polymerase chain reaction（PCR）. Of the 27 patients, 15 had MTLE and 12 did not. Resalts In brain tissues, positive rates of HHV-6 in refractory epilepsy, MTLE, and non-MTLE groups were 44.4%, 66.7% and 16.7% respectively, and no positive cases were found in the control group. Also 11 positive hematological cases were found in the MTLE group, 3 in the non-MTLE group and 1 in the control group. Conclusion Intractable epilepsy, especially mesial temporal lobe epilepsy has a close relation ship to human herpesvirus-6.

关 键 词：癫痫 疱疹病毒6型 人 聚合酶链反应 

分 类 号：R725[医药卫生—儿科]