补体因子H和肾上腺髓质素对高糖培养的HBZY-1大鼠系膜细胞的调节作用  

Regulative effect of complement factor H and adrenomedullin on HBZY-1 rat mesangial cells cultured under high glucose concentration

作　　者：耿厚法[1] 鲁一兵[1] 蒋秀琴[1] 李慧敏[1] 许旌[1] 缪珩[1] 

机构地区：[1]南京医科大学第二附属医院内分泌科,210011

出　　处：《中华内分泌代谢杂志》2008年第3期319-321,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：研究补体因子H和肾上腺髓质素对高糖培养的HBZY-1大鼠系膜细胞转化生长因子β1（TGF-β1）及细胞外基质（ECM）分泌的影响。结果提示联合应用肾上腺髓质素和补体因子H可显著抑制HBZY-1细胞TGF-β1及ECM的过度分泌而表现出一定的肾脏保护作用。The renal protective effect of complement factor H （CFH） and adrenomedullin （AM） on rat mesengial cells （ HBZY-1 ） cultured under high glucose levels was investigated. Resuhs indicated that AM and CFH inhibited the expressions of transforming growth factor-β1 and extracellular matrix in HBZY-1 cells, suggesting that CFH and AM in combination seem to show some renal protective effects on diabetic nephropathy.

关 键 词：补体因子H 肾上腺髓质素 糖尿病 

分 类 号：R587.2[医药卫生—内分泌]