西藏地区60例慢性乙型肝炎患者病毒基因分型及分布特点  

Genotypic characteristics of hepatitis B virus isolated from 60 Tibet patients

作　　者：龚学红[1] 王金蕾[2] 孟成艳[2] 金嘉琳[2] 张文宏[2] 

机构地区：[1]西藏自治区第二人民医院传染科,拉萨850002 [2]复旦大学附属华山医院传染科

出　　处：《中华传染病杂志》2008年第5期309-312,共4页Chinese Journal of Infectious Diseases

摘　　要：目的了解西藏地区HBV基因型分型及分布特点。方法选择2000年1月至2004年3月西藏地区HBsAg阳性的藏族HBV感染者60例。采用S基因序列分析法检测HBV基因型，并分析相应的前C／C区基因序列特点。结果60例HBV样本基因型中，59例为DC混合型，1例为Dbc混合型，其前C／C基因与B、C基因型均发生重组。结论本次调查HBV基因型为Dc混合型和Dbc混合型，无纯D型及其他基因型。Objective To investigate the genotypic characteristics of hepatitis B virus （HBV） in Tibet. Methods Serum samples from 60 cases of hepatitis B in Tibet Autonomous Region were collected from January 2000 to March 2004. HBV genotypes were analyzed by sequencing S region and precore/core region. Results HBV isolated from 60 cases were all found to be D genotype by S region sequencing. Dc mixture was found in 59 cases, showing the recombination between their precore/core gene and genotype B virus at 1804-2299 nucleotide. The other one case showed Dbc mixture genotype, showing recombination between its precore/core gene and genotype B and C genes. Conclusions All Tibet cases in this study show mixture genotype D with recombination with genotype C or both genotype B and C at precore/core region. No case of pure genotype D is found.

关 键 词：肝炎病毒 乙型 肝炎 乙型 慢性 基因型 西藏 

分 类 号：R512.62[医药卫生—内科学] R512.8[医药卫生—临床医学]