术后镇痛对CD_(25)表达及T细胞亚群影响的临床研究  

THE CLINICAL INVESTIGATION OF POSTOPERATIVE ANALGESIA ON THE T CELL SUBPOPULATIONS AND CD_(25) EXPRESSION

作　　者：万兆星[1] 王升[1] 刘晶涛[1] 侯建民[1] 

机构地区：[1]河南省安阳地区医院,安阳455000

出　　处：《中国疼痛医学杂志》2008年第3期145-146,共2页Chinese Journal of Pain Medicine

摘　　要：目的:研究术后镇痛对CD25表达及T细胞亚群的影响。方法:将40例择期经腹胆囊切除术患者,随机分为二组。A组20例无术后镇痛,B组20例有术后镇痛。于麻醉前(T0)、麻醉后1小时(T1)、手术后24小时(T2)、手术后72小时(T3),分别采取外周静脉血采用流式细胞学法分别检测T细胞亚群及淋巴细胞CD25。结果:术后,A组T细胞亚群百分数及淋巴细胞CD25水平下降缓慢,B组在短时间内(24小时内)迅速下降至术前水平,两组相比有显著性差异(P<0.05)。结论:术后镇痛可较好地维护机体免疫功能,使机体免疫功能快速恢复至术前状态。Objective： To study the effects of postoperative analgesia on the T cell subpopulation and CD25 expression. Methods： Forty patients undergoing elective laparoseopic choleeystectomy were randomly divided into two groups with 20 cases in each group, group A without postoperative analgesia and group B with postoperative analgesia. Mononuclear cells and ergthrocytes were simultaneously isolated before anesthesia（T0） , one hour after anesthesia（ T1 ）, twenty-four hour （ T2） and seventy-two hour（ T3 ） after operation. T cell subpopulation and CD25 expression were identified respectively by flow cytometryy. Results： The percentages of the T cell subpopulation and CD25 cell in group B were decreased rapidly than those in group A, and there was a significant difference （P 〈 0.05）. Conclusion： Postoperative analgesia could be beneficial to protect immunoreaction and recover to the normally immunological state.

关 键 词：术后镇痛 免疫 胆囊切除术 T细胞亚群 CD25 

分 类 号：R614[医药卫生—麻醉学]