阿魏酸钠对2型糖尿病脂代谢和C反应蛋白的影响  

The effect of sodium ferulat on lipid metabolism and C-reactive protein in patients with type 2 diabetes mellitus

作　　者：胡欣[1] 张弘[2] 陆新虹[1] 郝丽莉[1] 

机构地区：[1]广西壮族自治区南溪山医院内分泌科,广西桂林541002 [2]广西壮族自治区南溪山医院检验科,广西桂林541002

出　　处：《华夏医学》2008年第2期211-212,共2页Acta Medicinae Sinica

基　　金：广西壮族自治区卫生厅科研基金资助课题(桂卫Z2005115)

摘　　要：目的:探讨阿魏酸钠(SF)对2型糖尿病(T2DM)脂代谢和C反应蛋白(CRP)的影响。方法:35例T2DM患者每日静脉滴注SF0.3g2周,治疗前后查血脂、超敏C反应蛋白(sCRP)、内皮素(ET)及血清抗氧化酶。结果:SF能明显降低总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、ET、sCRP的浓度(P<0.01,P<0.05),能明显提高血液过氧化氢酶(CAT)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活性(P<0.01,P<0.05)。结论:SF能改善T2DM患者的抗氧化酶活性,降低SCRP及血脂水平,对糖尿病慢性并发症具有防治作用。Objective：To investigate sodium ferulat （SF） to diabetes antioxidant enzyme and C-reactive protein in patients with type 2 diabetes mellitus. Methods ： Serum TC, TG, HDL-C, LDL-C, sCRP, ET, CAT, SOD and GSH-Px were detected in 35 diabetes patients. The blood samples were detected after given SF 0. 3g/d for 2 weeks. Results ; The content of TC,TG,LDL-C,sCRP,ET in serum were decreased （P〈0.01, P〈0. 05）, activities of CAT, SOD, GSH-PX in serum increased. Conclusion：SF can improve the activity of serum antioxidant enzymes and decrease the level of serum sCRP and blood lipids in diabetes. SF has a value in the treatment of diabetic chronic complication.

关 键 词：阿魏酸钠 糖尿病 血脂 C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]