妊娠β地中海贫血患者红细胞及网织红细胞观察  

An observation on erythrocyte and reticulocyte in pregnant women with β-thalassemia

作　　者：赵应斌[1] 黎华莲[1] 丁燕玲[1] 刘钢毅[1] 刘宇[1] 

机构地区：[1]广西柳州市人民医院,545001

出　　处：《实用医学杂志》2008年第11期1994-1995,共2页The Journal of Practical Medicine

摘　　要：目的:观察妊娠的β地中海贫血(β地贫)妇女红细胞参数:平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血红蛋白浓度(MCHC)、红细胞体积分布宽度(RDW)。网织红细胞参数:网织红细胞百分率(RET%)、网织红细胞绝对值(RET#)、未成熟网织红细胞指数(IRF)、低荧光强度网织红细胞(LFR)、中荧光强度网织红细胞(MFR)、高荧光强度网织红细胞(HFR)在妊娠后的变化情况。方法:用SysmexXE-2100全自动血液分析仪测定β地贫妊娠妇女红细胞及网织红细胞,将各项测定结果与正常妊娠妇女、非妊娠β地贫妇女进行比较。结果:β地贫妊娠妇女的MCV、MCH低于正常妊娠妇女,RDW高于正常妊娠妇女;β地贫妊娠妇女RET%、RET#、IRF、MFR、HFR高于正常妊娠妇女,LFR低于正常妊娠妇女。β地贫妊娠妇女的MCV、MCH、IRF、MFR、HFR高于β地贫非妊娠妇女,LFR低于β地贫非妊娠妇女。结论:β地贫妇女在妊娠后造血功能会更旺盛,红细胞、网织红细胞参数变化更明显,MCV、MCH、RDW、RET%、RET#、IRF、LFR、MFR、HFR可作为产前地中海贫血筛查的参考指标。Objective To explore the change in erythrocyte parameters （MCV, MCH, MCHC, and RDW） and reticulocyte parameters （RET%, RET#, IRF, LFR, MFR, and HFR） in pregnant women with β-thalassemia. Methods Erythrocyte and reticulocyte parameters were measured in pregnant women with β-thalassemia by a Sysmex XE-2100 automated hematology analyzer and the outcomes were compared with those from healthy pregnant women and from non- pregnant women with β-thalassemia. Results The levels of MCV, MCH, and LFR were lower but the levels of RDW, RET%, RET# , IRF, MFR, and HFR were higher in pregnant women with β-thalassemia than in healthy pregnant women. The levels of MCV, MCH, IRF, MFR and HFR were higher whereas LFR level was lower in pregnant women with β- thalassemia than in non-pregnant women with β-thalassemia. Conclusions The hematopoietic function becomes more active and the changes in erythrocyte and reticulocyte parameters are more obvious in pregnant women with β-thalassemia. MCV, MCH, RDW, RET%, RET#, IRF, LFR, MFR, and HFR can be used as reference markers for screening thalassemia in pregnant women.

关 键 词：Β地中海贫血 妊娠 红细胞 网织红细胞 

分 类 号：R714.2[医药卫生—妇产科学]