中草药挥发油类透皮吸收促进作用研究进展  

Advances in the volatile oils from traditional Chinese medicine as transdermal absorption enhancers

作　　者：李莉[1] 韩国柱[2] 

机构地区：[1]大连友谊医院药剂科,大连116011 [2]大连医科大学药理教研室,大连116044

出　　处：《中国新药杂志》2008年第11期914-918,946,共6页Chinese Journal of New Drugs

摘　　要：20世纪90年代以来,中草药挥发油类及其活性成分透皮吸收促进作用的研究报告日益增多,并已展示出广阔的临床应用前景。文献报道较多的这类促进剂包括薄荷油、柠檬油、桉油、丁香油、蛇床子油、当归挥发油、松节油等。其主要促渗活性成分多为单萜和倍半萜类化合物。该类天然促渗剂具有促渗作用强、起效快、不良反应小等特点。它们主要通过改变皮肤角质层细胞的有序排列、"拉动"效应以及增强皮肤角质层水合作用等机制发挥促渗作用。该类促渗剂的化学结构和理化性质、促渗剂的浓度以及促渗剂的联合应用均可影响其促渗作用。现综述近年来国内外该类透皮吸收促进剂的作用特点、机制及其影响因素方面的研究进展。Since 90s of 20 th century, the volatile oils of traditional Chinese medicine as transdermal absorption enhancers （TAE） have been increasingly reported; they show broad prospects in clinical application. Such a type of the oils include peppermint oil, limoni oil, eucalyptin oil, caryophil oil, cnicium seed oil, angelica sinen- sis volatile oil, and turpent oil. Their active substances for the penetration-enhancement have been found to be mainly monoterpens and sesquiterpenes. Compared with azone, a chemically synthetic TAE, these natural TAEs are characterized by potent penetration-enhancing effect, rapid onset of action and mild side effect. They exert penetration-enhancing effects mainly through altering the arrangement of stratum corneum cells of skin, ＇ pull＇ effect, and hydration-enhancing effect. The penetration-enhancing activity of these TAEs can be influenced by their chemi- cal structures, physico-chemical properties, and concentration, as well as combined uses. This article reviewed domestic and international advances in the study of this group of TAE on the penetration-enhancing characteristics, action mechanisms and influencing factors.

关 键 词：中草药 挥发油 透皮吸收促进剂 

分 类 号：R943[医药卫生—药剂学]