间羟基苯乙胺的合成  

SYNTHESIS OF 3-(2-AMINOETHYL)-PHENOL

作　　者：程广斌[1] 孙海龙[1] 

机构地区：[1]南京理工大学化工学院,江苏南京210094

出　　处：《精细石油化工》2008年第3期52-55,共4页Speciality Petrochemicals

摘　　要：以间羟基苯甲醛为原料经过缩合,催化加氢合成了间羟基苯乙胺,考察了水对缩合反应以及反应条件对催化加氢的影响。确定了以5%Pd/C为催化剂加氢的优化条件:反应时间3.5 h,反应压力1.5 MPa,反应温度100℃,总收率可达75.4%。3-（2-Aminoethyl）-phenol was synthesized with 3-nitrobenzaldehyde as raw material though condensation and catalytic hydrogenation. The overall yield was up to 75.4%. Effect of water on the condensation and effect of process conditions on the catalytic hydrogenation were investigated. The optimum conditions for the catalytic hydrogenation were obtained as follows, reaction time 3.5 h, reaction pressure 1.5 MPa, and reaction temperature 100 ℃over 5% Pd/C catalyst.

关 键 词：间羟基苯乙胺 间羟基苯甲醛 缩合 催化加氢 

分 类 号：TQ246[化学工程—有机化工]